Publications by authors named "Gleice C Leite"
Article Synopsis
- - The study investigates the effectiveness of fosfomycin as a treatment against multi-resistant A. baumannii infections and aims to understand its resistance mechanisms by analyzing 32 bacterial isolates.
- - Results showed a wide range of fosfomycin susceptibility (MIC values from 32 to ≥256 mg/L), with specific resistance genes found in some isolates, including mutations in key metabolic pathways.
- - Key findings include the absence of fosA and fosB genes in all isolates, presence of the fosX gene in four, and notable mutations in the MurA enzyme and adenylate cyclase that may impact fosfomycin resistance mechanisms in A. baumannii.
Synergy between piperacillin-tazobactam and meropenem against KPC-producing was recently demonstrated. We sought to test the combination against a broader range of serine carbapenemase producers. We tested the combination against 10 KPC-producing and 10 OXA-48 family-producing isolates.
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- Multidrug-resistant Gram-negative bacteria, including Enterobacterales, pose a global health threat as treatment options decrease, leading to this study focusing on 50 resistant isolates and their susceptibility to less-used antibiotics.
- The study examined various strains, revealing that many carried resistance genes, with a high prevalence of antimicrobial resistance and variable susceptibility to older drugs like tigecycline, minocycline, and ceftazidime/avibactam.
- Results indicated that while tigecycline exhibited promising effectiveness against most Gram-negative strains, other antibiotics like chloramphenicol showed poor performance, highlighting the need for continued research on alternative treatments.
Article Synopsis
- The study evaluates two alternative methods (disk approximation and MIC:MIC ratio) for testing antibiotic combinations against multidrug-resistant bacteria, compared to the gold standard, the time-kill assay.
- Results showed varying levels of agreement between the methods, with the disk approximation method showing a range of 20-93% agreement with time-kill assays.
- The findings suggest that these simpler methods could be useful for clinical microbiology laboratories in assessing antibiotic synergy, particularly for certain resistant strains.
Treatment of infections caused by A. baumannii is becoming a challenge due to the ability to develop multidrug-resistance, virulence, and high mortality. We described the colistin resistance and virulence genes present in sixA.
View Article and Find Full Text PDFSynergistic Effect of Ceftazidime-Avibactam with Meropenem against Panresistant, Carbapenemase-Harboring and Investigated Using Time-Kill and Disk Approximation Assays.
Antimicrob Agents Chemother
May 2019
Article Synopsis
- - The study assessed how effective ceftazidime-avibactam is alone and in combination with meropenem against 11 multi-drug resistant bacteria, particularly those with oxacillinases.
- - Results showed that ceftazidime-avibactam worked really well, especially when used with meropenem, against these resistant strains.
- - The disk approximation method used in the study effectively identified synergistic interactions in the treatment of infections.
Purpose: Carbapenem resistance in P. aeruginosa is increasing worldwide. In Brazil, SPM-1 is the main P.
View Article and Find Full Text PDFThe study investigated the effect of antibiotic combinations against 20 clinical isolates of A. baumannii (seven colistin-resistant and 13 colistin-susceptible) with different resistance mechanisms. Clinical data, treatment, and patient mortality were evaluated.
View Article and Find Full Text PDFObjective: To describe the analysis of geographical and temporal distribution of DNA profiles determined by pulsed-field gel electrophoresis (PFGE) of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from hospitalized patients in a tertiary care university hospital in Brazil.
Methods: Ninetynine samples of MRSA obtained from 89 patients in the period 1999-2004 were studied. MRSA strains were isolated from central venous catheters (33 isolates) and bloodstream infections (66 strains).