Publications by authors named "Gleb A Bazilevsky"
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View Article and Find Full Text PDFATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Accordingly, aberrant ACLY activity is observed in many diseases. Here we report cryo-EM structures of human ACLY, alone or bound to substrates or products.
View Article and Find Full Text PDFATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes. ACLY is aberrantly regulated in many cancers, cardiovascular disease, and metabolic disorders. However, the molecular mechanisms determining ACLY activity and function are unclear.
View Article and Find Full Text PDFArticle Synopsis
- Over the last ten years, researchers have found various histone acyl post-translational modifications (acyl-PTMs), but their functions are still being explored.
- The study uses high-resolution mass spectrometry to accurately measure eight acyl-PTMs both in living organisms and through enzymatic tests, finding that specific histone acetyltransferases (HATs) work better with short-chain acyl-CoAs than larger ones.
- The research shows a strong correlation between acyl-CoA availability and acyl-PTM levels, indicating that both enzymatic actions and non-enzymatic processes influence the abundance of these histone modifications.