Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing.

Crop genomes accumulate deleterious mutations-a phenomenon known as the cost of domestication. Precision genome editing has been proposed to eliminate such potentially harmful mutations; however, experimental demonstration is lacking. Here we identified a deleterious mutation in the tomato transcription factor SUPPRESSOR OF SP2 (SSP2), which became prevalent in the domesticated germplasm and diminished DNA binding to genome-wide targets.

Under which conditions do extreme events support a paradigm shift? Studying focusing events during two centuries of Swiss flood risk management.

Unlabelled: Extreme weather events affect many areas around the world. How a country or region reacts to it can take many forms. In this article, we concentrate on policy responses, as typically found in laws, acts, or strategies.

Genome-wide association analysis uncovers rice blast resistance alleles of Ptr and Pia.

A critical step to maximize the usefulness of genome-wide association studies (GWAS) in plant breeding is the identification and validation of candidate genes underlying genetic associations. This is of particular importance in disease resistance breeding where allelic variants of resistance genes often confer resistance to distinct populations, or races, of a pathogen. Here, we perform a genome-wide association analysis of rice blast resistance in 500 genetically diverse rice accessions.

Early identification of cancer-related malnutrition in patients with colorectal cancer before and after surgery: a literature review.

Purpose: The aim of this literature review is to provide a comprehensive overview of methods for early identification of cancer-related malnutrition and/or risk of malnutrition in patients with colorectal cancer. The focus is also on applicability and feasibility of the use of nutritional tools in oncology clinical practice.

Methods: The literature search was conducted from November to December 2020 in the health science databases by two independent persons.

Employment trajectories of young women with breast cancer: an ongoing prospective cohort study in Italy and Switzerland.

Purpose: Despite extensive research on cancer and work-related outcomes, evidence from longitudinal cohort studies is limited, especially in young women with breast cancer (BC). We aimed to investigate employment trajectories in young BC survivors and to identify potential factors associated with changes in work activity.

Methods: The HOHO European prospective multicenter cohort study enrolled 300 young women (≤ 40 years) with newly diagnosed BC.

[Promoting physical activity in women during breast cancer therapy: A mixed methods evaluation of a nursing counselling intervention].

Promoting physical activity in women during breast cancer therapy: A mixed methods evaluation of a nursing counselling intervention Physical activity is associated with improved quality of life in women during breast cancer treatment. However, how physical activity behaviour of patients changes in the first months after the start of the treatment and what role nursing counselling can play has not yet been sufficiently investigated. To observe differences in physical activity behaviour in women with breast cancer at the time of the initiation of the therapy and six months later, and to explore patients' and health professionals' perspective on a nursing counselling intervention on physical activity.

Prevalence of BRD-Related Viral Pathogens in the Upper Respiratory Tract of Swiss Veal Calves.

The prevention of bovine respiratory disease is important, as it may lead to impaired welfare, economic losses, and considerable antimicrobial use, which can be associated with antimicrobial resistance. The aim of this study was to describe the prevalence of respiratory viruses and to identify risk factors for their occurrence. A convenience sample of 764 deep nasopharyngeal swab samples from veal calves was screened by PCR for bovine respiratory syncytial virus (BRSV), bovine parainfluenza-3 virus (BPI3V), bovine coronavirus (BCoV), influenza D virus (IDV), and influenza C virus (ICV).

Supporting older adults with chemotherapy treatment: A mixed methods exploration of cancer caregivers' experiences and outcomes.

Purpose: Due to delivery of chemotherapy being mostly in ambulatory care settings, support of people with cancer relies heavily on caregivers (e.g. relatives).

How flood risks shape policies: flood exposure and risk perception in Swiss municipalities.

Despite an increasing number of people exposed to flood risks in Europe, flood risk perception remains low and effective flood risk management policies are rarely implemented. It becomes increasingly important to understand how local governments can design effective flood risk management policies to address flood risks. In this article, we study whether high flood exposure and flood risk perception correlate with the demand for a specific design of flood risk management policies.

Fertility concerns, preservation strategies and quality of life in young women with breast cancer: Baseline results from an ongoing prospective cohort study in selected European Centers.

Objectives: Most research addressing needs and concerns of young patients with breast cancer (≤40 years) is retrospective. The HOHO European protocol is a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns. Here we report the baseline data and focus on predictors of fertility concerns.

Recommendations for symptom management in women with vulvar neoplasms after surgical treatment: An evidence-based guideline.

Purpose: To develop an evidence-based guideline for nurses and other health care professionals involved in pre- and postsurgical care of women with vulvar cancer (VC) or vulvar intraepithelial neoplasia (VIN).

Methods: This evidence-based guideline was developed according to six domains of the methodological framework AGREE II. Literature research with focus on cancer care, symptom management and self-management/counselling was conducted from April to August 2013 in the databases CINAHL, Cochrane Library, PsycINFO, PubMed as well as in 14 international guideline databases.

Preventive therapy for breast cancer: a consensus statement.

In March, 2010, a group of breast cancer experts met to develop a consensus statement on breast cancer prevention, with a focus on medical and therapeutic interventions. We present the conclusions in this Review. First we agreed that the term chemoprevention is inappropriate and suggested that the term preventive therapy better represents this feature of management.

Breast cancer patients on endocrine therapy reveal more symptoms when self-reporting than in pivotal trials: an outcome research study.

Objectives: The purpose of this investigation was firstly to assess the overall frequency of subjectively experienced symptoms self-reported by patients receiving endocrine therapy and secondly to compare these symptoms with side effects assessed by clinicians in pivotal trials.

Methods: Unselected patients with early and advanced breast cancer receiving endocrine therapy were approached consecutively during a routine outpatient visit. They received a questionnaire called Checklist for Patients with Endocrine Therapy (C-PET), a validated self-assessment tool to determine prespecified symptoms associated with endocrine therapy.

[The assessment of nursing care needs in cancer patients].

In order to explore the status quo of the assessment of nursing care needs in newly admitted inpatients on oncology wards a survey in a German university hospital was carried out. Research questions included: Do the nurses collect data regarding nursing care needs of admitted cancer patients? When are the data collected? What data are collected? What is documented, when is it documented, and is the patient involved in the documentation? What, if any, factors on the part of nurses have an impact on the way in which these data are collected? Two methods were used to collect research data: nursing documents of hospitalised cancer patients were analysed (n = 68), followed by an interview with the nurses (n = 81). Beforehand, an instrument was developed and tested for both investigative methods.

Endocrine symptom assessment in women with breast cancer: what a simple "yes" means.

Goals Of Work: To investigate the self-reported symptoms related to endocrine therapy in women with early or advanced breast cancer and the impact of these symptoms on quality of life (QL) indicators.

Materials And Methods: Symptom occurrence was assessed by the Checklist for Patients on Endocrine Therapy (C-PET) and symptom intensity was assessed by linear analogue self-assessment (LASA) indicators. Patients also responded to global LASA indicators for physical well-being, mood, coping effort and treatment burden.

Fatigue and menopausal symptoms in women with breast cancer undergoing hormonal cancer treatment.

Background: Hormonal treatment for women with breast cancer is frequently proposed in the adjuvant as well as in the palliative setting. Therefore, many women are confronted with early menopause and prolonged oestrogen deprivation and consequently with a variety of quality of life issues, such as menopausal symptoms and fatigue.

Patients And Methods: It was the aim of this study to explore the occurrence and frequency of menopausal symptoms in women with breast cancer, undergoing hormonal cancer treatment and to investigate their relationship with fatigue.

[Breast cancer prevention behaviour: a perspective of women from three language regions of Switzerland].

Unlabelled: Swiss women show, together with women from the Netherlands, France, Belgium, Sweden, Finland, England and Germany, a very high incidence of breast cancer in Europe. Whilst the evidence for primary cancer prevention is slowly growing, its strategies can not yet be implemented in clinical prevention programmes. Therefore, secondary prevention, early detection of cancer, remains the main focus for reducing breast cancer mortality.

Chemotherapy-induced nausea and vomiting in routine practice: a European perspective.

Goals Of Work: The aim of this study was to evaluate the occurrence of chemotherapy-induced nausea and vomiting (CINV) and its effect on patients' ability to carry out daily life activities following moderately to highly emetogenic, first-cycle chemotherapy in routine practice in cancer centers of four different European countries.

Patients And Methods: This was a prospective, cross-sectional, nonrandomized, self-assessment study in 249 patients enrolled from cancer centers in Spain, Austria, Germany, and Switzerland. The study population consisted of 78% women, with a mean age of 54.

Quality and efficacy of educational materials on cancer-related fatigue: views of patients from two European countries.

Cancer-related fatigue is a symptom with great implications for the quality of life of those that experience it. It is regarded as one of the most distressing symptoms that people with cancer develop. Its aetiology is complex, and although the mechanisms underlying fatigue have not been fully clarified it is evident that it is exacerbated by treatments intended to cure or palliate the disease.