Publications by authors named "Glauber M Leitao"
Article Synopsis
- - Receptor tyrosine kinases (RTKs) play crucial roles in cell functions like growth and differentiation, and when their signaling is disrupted, it can lead to tumors and make treatments less effective.
- - This study analyzed gene expressions of specific RTKs (TAM, RON, EPHA2, and MET) in breast cancer tissues using qPCR, focusing on how these expressions relate to clinical data.
- - Findings suggest that the expression of TYRO3, MET, and EPHA2 is associated with factors like tumor subtype, patient age, and lifestyle choices such as smoking and obesity, indicating their potential significance in breast cancer.
Background: It is uncertain whether myocardial fluorodeoxyglucose uptake occurs solely due to physiological features or if it represents a metabolic disarrangement under chemotherapy.
Objective: To investigate the chemotherapy effects on the heart of patients with lymphoma by positron emission tomography associated with computed tomography scans (PET/CT) with 2-deoxy-2[18F] fluoro-D-glucose (18F-FDG PET/CT) before, during and/or after chemotherapy.
Methods: Seventy patients with lymphoma submitted to18F-FDG PET/CT were retrospectively analyzed.
Unlabelled: CYP2D6 is a high polymorphic enzyme from P450, responsible for metabolizing almost 25% of drugs. The distribution of different mutations among CYP2D6 alleles has been associated with poor, intermediate, extensive and ultra-metabolizers.
Aim: To evaluate how missenses mutations in CYP2D6*7 and CYP2D6*14A poor metabolizer alleles affect CYP2D6 stability and function.
Article Synopsis
- * Pretreatment OPN levels were found to be higher in patients with more advanced disease stages, and lower OPN levels were linked to better treatment responses.
- * High pretreatment OPN levels correlated with shorter survival times, suggesting that OPN could serve as a prognostic marker in HNSCC treatment strategies.
High-dose cisplatin concurrent to conventionally delivered radiotherapy is associated with unacceptable toxicity in unresectable, non-metastatic stage IV head and neck squamous cell carcinoma.
Eur Arch Otorhinolaryngol
December 2007
Article Synopsis
- - Unresectable head and neck squamous cell carcinoma (HNSCC) includes a diverse group of patients, specifically in stages III and IV, and this study investigated the feasibility of a specific treatment regime involving cisplatin and radiotherapy for stage IV patients.
- - A total of 30 patients participated in the study, where they received a combination of 70 Gy radiation and cisplatin, resulting in an overall response rate of 60%, with some patients achieving complete or partial tumor responses.
- - The treatment was associated with significant side effects, including toxicities affecting 26 patients and three deaths, with median progression-free survival of 8 months and overall survival of 17.3 months noted, indicating challenges in administering