Background: Retroperitoneal cystadenocarcinomas are rare lesions, the majority of cases presented as one-patient reports.
Methods: We present two cases of retroperitoneal cystadenocarcinoma, both in women of reproductive age: one with aggressive behavior, and the remaining case, with a more indolent clinical evolution.
Results: One case presented as pelvic tumor, was treated with surgical resection of the disease, but manifested with recurrent disease a few months later despite use of chemotherapy.