Publications by authors named "Gladys Kasangaki"
Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub-study of the ODYSSEY randomized controlled trial.
Linda Namutebi Barlow-Mosha Grace Miriam Ahimbisibwe Elizabeth Chappell Pauline Mary Amuge Annet Nanduudu Gladys Kasangaki
J Int AIDS Soc
September 2023
Article Synopsis
- Dolutegravir-based antiretroviral therapy (ART) is recommended for treating children and adolescents with HIV, but earlier studies raised concerns about its potential link to neural tube defects.
- A sub-study was conducted within the ODYSSEY trial in Uganda to assess the impact of dolutegravir on folate and vitamin B12 levels, essential for neural tube development, compared to standard care treatments.
- Results indicated that children on dolutegravir had significantly higher plasma and RBC folate levels at both week 4 and week ≥96 compared to those on standard treatment, suggesting a positive effect of dolutegravir on folate status.