The Administration of Levodopa in a Patient With Parkinson's Disease Using a Novel Maxillofacial Route: A First-in-Human Report.

Parkinson's disease is characterized by the loss of nigrostriatal dopaminergic neurons in the brain. Dopamine cannot be administered systemically because it does not cross the blood-brain barrier. Oral levodopa remains the gold standard to date.

Evaluation of the Anti-microbial Efficacy of a Novel Endodontic Irrigant Against Enterococcus faecalis: An In Vitro Study.

Introduction: is a constant microbiome that plays an inevitable role in the etiology of peri radicular lesions after endodontic treatment, chronic and, apical periodontitis and, recently, in periimplantitis. The effective biomechanical preparation and the use of potent irrigating solutions will permit bacterial neutralization and toxin inactivation, leading to the success of endodontic treatment. This study aimed to evaluate the "anti-microbial" efficacy of simvastatin (SMV) against faecalis as an endodontic irrigant.