Publications by authors named "Gladia C Hotan"
Objective: We perform a randomized trial to test the impact of electronic pill bottles with audiovisual reminders on oral disease modifying therapy (DMT) adherence in people with MS (PwMS).
Methods: Adults with multiple sclerosis (MS) taking an oral DMT were randomized 1:1 for 90 days to remote smartphone app- and pill bottle-based (a) adherence monitoring, or (b) adherence monitoring with audiovisual medication reminders. Optimal adherence was defined as the proportion of doses taken ±3 h of the scheduled time.
Article Synopsis
- A recent debate focuses on how the frontal and posterior cortices contribute to consciousness and unconsciousness, with posterior cortex disruption affecting dreams and frontal cortex activation necessary for perception.
- Researchers used anesthesia to observe changes in brain activity during states of unconsciousness in humans, noting significant shifts in slow-wave modulation across different cortical regions.
- The study found that as subjects became more deeply anesthetized, both frontal and posterior cortices were involved in a distinct brain state that disrupts consciousness, indicating that unconsciousness can involve different phases beyond just lack of awareness.
Background: Bright white light therapy (LT) can improve fatigue in several disease states but has not been studied in multiple sclerosis (MS).
Objective: To determine whether controlled home-based LT is feasible, tolerable, and well-adhered to in MS-associated fatigue.
Methods: A randomized, controlled trial of twice-daily 1-h bright white LT (BWLT) (10,000 lx, active arm) versus dim red LT (DRLT) (< 300 lx, control arm) was performed.
Progressive multifocal leukoencephalopathy: A 25-year retrospective cohort study.
Neurol Neuroimmunol Neuroinflamm
November 2019
Objective: To characterize the risk factors, clinical course, and treatment of patients with progressive multifocal leukoencephalopathy (PML) diagnosed and followed over a 25-year epoch at 2 academic hospitals.
Methods: Patients with a definite diagnosis of PML were identified by positive CSF PCR for JC virus or histopathology between January 1, 1994, and January 1, 2019. Demographic and PML-specific variables were recorded on symptomatic presentation and at follow-up, including risk factors, clinical outcome, neuroimaging findings, and modified Rankin Scale (mRS) score at last follow-up.
Purpose: Children with epilepsy in low-income countries often go undiagnosed and untreated. We examine a portable, low-cost smartphone-based EEG technology in a heterogeneous pediatric epilepsy cohort in the West African Republic of Guinea.
Methods: Children with epilepsy were recruited at the Ignace Deen Hospital in Conakry, 2017.
Background: Fatigue is the most commonly reported symptom among multiple sclerosis (MS) patients, more than a quarter of whom consider fatigue to be their most disabling symptom. However, there are few effective treatment options for fatigue. We aim to investigate whether supplemental exposure to bright white light will reduce MS-associated fatigue.
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