Publications by authors named "Gkeka E"
Ventriculo-meningitis or nosocomial meningitis/ventriculitis is a severe nosocomial infection that is associated with devastating neurological sequelae. The cerebrospinal fluid isolates associated with the infection can be Gram-positive or -negative, while the spp. is rarely identified.
View Article and Find Full Text PDFBackground: Endotype classification becomes the cornerstone of understanding sepsis pathogenesis. Macrophage activation-like syndrome (MALS) and immunoparalysis are the best recognized major endotypes, so far. Interferon-gamma (IFNγ) action on tissue macrophages stimulates the release of the cytotoxic chemokine CXCL9.
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- Researchers classified sepsis into four clinical phenotypes using a simplified algorithm based on six admission parameters in a study involving 1498 patients, including those with bacterial sepsis and severe COVID-19.
- The analysis found distinct characteristics and outcomes for the phenotypes, with Phenotype α showing low mortality risk and Phenotype δ having the highest mortality.
- The study concludes that this phenotyping method is effective for predicting outcomes in both bacterial sepsis and severe COVID-19, suggesting it could have important prognostic applications.
Objectives: It is suggested that sepsis may be classified into four clinical phenotypes, using an algorithm employing 29 admission parameters. We applied a simplified phenotyping algorithm among patients with bacterial sepsis and severe COVID-19 and assessed characteristics and outcomes of the derived phenotypes.
Design: Retrospective analysis of data from prospective clinical studies.
Background: Macrophage activation-like syndrome (MALS) and complex immune dysregulation (CID) often underlie acute respiratory distress (ARDS) in COVID-19. We aimed to investigate the effect of personalized immunotherapy on clinical improvement of critical COVID-19.
Methods: In this open-label prospective trial, 102 patients with ARDS by SARS-CoV-2 were screened for MALS (ferritin >4,420 ng/mL) and CID (ferritin ≤4,420 ng/mL and low human leukocyte antigen (HLA)-DR expression on CD14-monocytes).
The role of probiotics in the prevention of ventilator-associated pneumonia (VAP) remains inconclusive. The aim of this study was to assess the efficacy of a probiotic regimen for VAP prophylaxis in mechanically ventilated multi-trauma patients, intubated immediately after the injurious insult. In a randomized, placebo-controlled study enrolling multi-trauma patients, patients expected to require mechanical ventilation for >10 days were assigned at random to receive prophylaxis with a probiotic formula (n=59) or placebo (n=53).
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- The study analyzed the transcriptomic host response to SARS-CoV-2 in patients with COVID-19, comparing it to responses from other viral infections using RNA sequencing.
- Results showed that although COVID-19 gene expression changes were significantly correlated with other viral infections, there were 416 genes unique to COVID-19, indicating specific immune responses and evasion mechanisms.
- The findings reveal shifts in immune cell types during COVID-19, with increases in natural killer cells and M2 macrophages, helping to deepen our understanding of how the host responds to SARS-CoV-2.
Aims: The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece.
Methods: In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed critically ill patients from 8 hospitals throughout Greece, were analysed. All reported information stand through April 13th 2020.