Validated instruments in the evaluation and treatment outcomes of stress urinary incontinence in women.

Urinary incontinence is a highly prevalent condition. Although there are commonly used tools for the evaluation of urinary incontinence and measurement of treatment outcomes, there is no universally accepted standard. However, there are several validated instruments currently available and in use for assessment of patient-reported outcomes.

Non-clamped partial nephrectomy: techniques and surgical outcomes.

Objective: • To describe our technique of partial nephrectomy (PN) without vascular clamping with perioperative and short-term data to determine the safety, impact on renal function and oncological efficacy of this approach.

Patients And Methods: • We performed a retrospective review of 952 PNs done at our institution between 1987 and 2009. Patients undergoing ex vivo PN with auto-transplantation, patients with Von Hippel-Lindau disease and patients with incomplete follow-up information were excluded from the analysis.

P-cadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells.

Objective: To identify changes associated with P-cadherin expression in bladder cancer and evaluate the potential role of such events in determining the clinical outcome and cell behaviour, as the function of P-cadherin in normal epithelium is unknown, as is its potential role in neoplastic progression in different cancers.

Materials And Methods: In all, 536 bladder tumour specimens from 408 patients were assembled in seven tissue microarrays. Paraffin sections from each array were processed for immunohistochemistry to assess the expression of P-cadherin.

Prognostic significance of altered p120 ctn expression in bladder cancer.

Objective: To identify the frequency of change in the expression and localization of p120(ctn) in bladder tumours and its association with clinical outcomes, and to investigate the potential role of p120(ctn) in the migratory and invasive behaviour of bladder carcinoma cells.

Materials And Methods: In all, 425 superficial tumour specimens (Ta, Tis and T1) and 305 invasive (T2-T4) tumour specimens from 534 patients were assembled in 10 tissue microarrays. P120(ctn) immunostaining was scored for intensity and cellular localization and correlated with clinical variables and survival analysis.