Publications by authors named "Gizem Terzioglu"
Article Synopsis
- Reactive astrocytes are linked to Alzheimer’s disease (AD), and this study explores how genetic risk factors in these cells contribute to AD pathology using induced pluripotent stem cells (iPSCs) from individuals with varying cognitive outcomes.
- The research involves creating astrocytes from iPSCs of 44 individuals and employing RNA sequencing and mass spectrometry to profile molecular features, revealing consistent dysregulation in genes and pathways between iPSC-derived astrocytes and actual AD brain tissue.
- Notable findings include differences in protein levels related to cellular respiration and interferon responses, indicating that higher genetic risk for AD correlates with lower levels of protective interferon response proteins, and suggesting a new experimental framework for studying genetic influences on
Recent genetic studies on Alzheimer's disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes expressed in microglia. Several of these genes have been recognized for their central roles in microglial functions. Increasing evidence suggests that SHIP1, the protein encoded by the AD-associated gene INPP5D, is an important regulator of microglial phagocytosis and immune response.
View Article and Find Full Text PDFMicroglia and neuroinflammation play an important role in the development and progression of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted autophagy and inflammasome activation.
View Article and Find Full Text PDFThe regulator of G-protein signaling 14 (RGS14) is a multifunctional signaling protein that regulates post synaptic plasticity in neurons. RGS14 is expressed in the brain regions essential for learning, memory, emotion, and stimulus-induced behaviors, including the basal ganglia, limbic system, and cortex. Behaviorally, RGS14 regulates spatial and object memory, female-specific responses to cued fear conditioning, and environmental- and psychostimulant-induced locomotion.
View Article and Find Full Text PDFThe establishment and maintenance of cellular identity are crucial during development and tissue homeostasis. Epigenetic mechanisms based largely on DNA methylation and histone modifications serve to reinforce and safeguard differentiated cell states. Somatic cell nuclear transfer (SCNT) or transcription factors such as Oct4, Sox2, Klf4, c-MYC (OSKM) can erase somatic cell identity and reprogram the cells to a pluripotent state.
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