Publications by authors named "Gizem Ayan"
Background: The short form of the Dentin Hypersensitivity Experience Questionnaire (DHEQ-15) is a valid and reliable tool for Oral Health-Related Quality of Life (OHRQoL) studies. The aim of this study was cross-culturally adapt and validate the English version of DHEQ-15 for the Turkish language.
Methods: The Turkish version of the DHEQ-15 was developed using the forward-backward translation method.
Background/purpose: Our objective was to investigate real-world outcomes and treatment strategies in individuals affected by DADA2 using over 10-year period real-life experience.
Methods: This descriptive analysis encompassed all adult/pediatric patients with DADA2 from our Vasculitis Research Center prospective database. Patients on anti-TNF therapy have been specifically examined, analyzing the treatment's duration, indications, and outcomes.
Background/aim: Rheumatoid factor (RF) and anticitrullinated peptide (anti-CCP) are specific for rheumatoid arthritis (RA) diagnosis. However, they could be positive in other diseases and even in healthy populations. The aim was to investigate the prevalence of positive RF and anti-CCP antibodies in persons admitted to hospital for any reason and on a national scale.
View Article and Find Full Text PDFObjectives: To evaluate the risk of liver fibrosis and associated factors with the non-invasive fibrosis score-4 (FIB-4) index in patients with inflammatory arthritis using methotrexate (MTX).
Methods: Patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) who were followed up in the rheumatology outpatient clinic, who were on methotrexate only and for whom FIB-4 index was could be calculated at methotrexate initiation and follow-up were included. The FIB-4 index was calculated according to the following formula: age (years) × AST(IU/L)/(platelet count(10 (9)/L) × √ALT(IU/L)).
Two years after its inception, Young Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (Y-GRAPPA) has established itself as a productive network for junior investigators and clinicians. The group's achievements in the last year include updating the educational GRAPPA slide library, the "Bring a Derm" campaign to expand the GRAPPA community to include more dermatologists, and the publication of multiple "Do Not Miss" newsletters covering the highlights on PsDs from the major international conferences (American Academy of Dermatology [AAD] Annual Meeting, European Alliance of Associations for Rheumatology [EULAR] Congress, European Academy of Dermatology and Venereology [EADV] Congress, and American College of Rheumatology [ACR] Convergence).
View Article and Find Full Text PDFObjectives: We aimed to explore the radiographic definitions of types of New Bone formation (NBF) by focusing on the terminology, description and location of the findings.
Methods: Three systematic literature reviews were conducted in parallel to identify the radiographic spinal NBF definitions for spondyloarthritis (SpA), Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Osteorathritis (OA). Study characteristics and definitions were extracted independently by two reviewers.
Introduction: Pulmonary arterial hypertension (PAH) is a leading cause of mortality in systemic sclerosis (SSc). This nationwide study aims to describe real world treatment characteristics and assess survival rates of patients with SSc-PAH.
Methods: In this retrospective cohort study, patients with SSc-PAH were identified from Turkish Ministry of Health National Electronic Database (from January 2016 to September 2022), using ICD-10 codes.
This work presents a sensitive and accurate analytical method for the determination of phenytoin at trace levels in domestic wastewater and synthetic urine samples by gas chromatography-mass spectrometry (GC-MS) after the metal sieve-linked double syringe liquid-phase microextraction (MSLDS-LPME) method. A metal sieve was produced in our laboratory in order to disperse water-immiscible extraction solvents into aqueous media. Univariate optimization studies for the selection of proper extraction solvent, extraction solvent volume, mixing cycle, and initial sample volume were carried out.
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- A study examined cancer rates in patients with ANCA-associated vasculitis (AAV) by comparing them to cancer risks in the Turkish population and identifying independent risk factors.
- Of the 461 AAV patients tracked, 19 developed cancer after an average follow-up of about 3.4 years, with higher cancer risks noted in older males and those with anti-PR3-ANCA positivity.
- The overall cancer risk for AAV patients was 2.1 times higher than that of the general population, highlighting the need for targeted cancer screening, especially for lung and head-neck cancers in older male patients.
Article Synopsis
- The study gathered data on 358 patients with polyarteritis nodosa (PAN) from nine countries, analyzing demographics, clinical features, and survival rates over 30 years.
- Findings showed common symptoms such as constitutional issues, skin lesions, joint pain, and neurological problems, with a significant relapse rate of 48.5% during an average follow-up of nearly five years.
- Survival rates for systemic PAN showed a decline over time, with important risk factors for mortality including older age, high serum creatinine levels, and involvement of the gastrointestinal system or central nervous system.
Article Synopsis
- The study aimed to translate and culturally adapt the modified Short Questionnaire to Assess Health-enhancing physical activity (mSQUASH) into Turkish, using a systematic approach that included expert reviews and patient feedback.
- The translation process was straightforward, with minor issues resolved through expert consensus; the Turkish mSQUASH was found to be clear, relevant, and easy for patients to understand, though some sport examples were modified to better fit Turkish culture.
- The final Turkish version of mSQUASH demonstrated good initial validity and usability, but further evaluation of its psychometric properties is necessary before it can be fully implemented in clinical settings.
Objectives: We aimed to determine the choice of biologic/targeted synthetic disease-modifying anti-rheumatic drugs (b/ts-DMARDs), factors associated with the development of chronic kidney disease (CKD), and mortality in RA patients with CKD receiving b/ts-DMARDs.
Methods: Two thousand one hundred forty-one RA (79.4% female) patients were included in the analysis from the HUR-BIO prospective registry.
Objectives: An acidogenic diet, by disrupting the blood pH equilibrium, can contribute to metabolic acidosis and lead to inflammation. Therefore, we hypothesized that dietary acid load (DAL) increases disease activity and inflammation in psoriatic arthritis (PsA) patients.
Methods: This study was conducted with 58 obese/overweight patients, aged 20-65 years.
Apical fibrobullous lung disease in spondyloarthritis patients with biologic DMARDs indication.
Rheumatology (Oxford)
April 2024
Article Synopsis
- * out of 2489 SpA patients examined, only 36 (1.4%) were diagnosed with AFLD, and those patients were typically older, more likely to be male, heavy smokers, and had longer disease durations.
- * it emphasizes the need for careful diagnosis, as AFLD symptoms can mimic tuberculosis, especially in males and those with a history of prolonged disease.
Young-GRAPPA (Y-GRAPPA) was introduced at the 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting. Here we present the 1-year progress of Y-GRAPPA and future plans of this enthusiastic group of young clinicians and early career researchers interested in psoriasis and psoriatic arthritis.
View Article and Find Full Text PDFIntroduction: This study aimed to assess the incidence of hematologic malignancy (HM) among inflammatory arthritis (IA) patients receiving tumor necrosis factor inhibitors (TNFi) compared with the general Turkish population.
Methods: HUR-BIO (Hacettepe University Rheumatology Biologic Registry) is a single-center biological disease-modifying anti-rheumatic drug (bDMARD) registry since 2005. Patients with IA, including rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis who had at least one visit after the TNFi were screened from 2005 to November 2021.
Article Synopsis
- The study evaluated the mortality rates of patients with Psoriatic Arthritis (PsA) before and during the COVID-19 pandemic by analyzing data from a Turkish registry linked to the Cause of Death Registry.
- Findings revealed that the crude mortality rate in PsA patients doubled during the pandemic, with noticeable increases in both genders but more significant in females.
- The research concluded that pre-pandemic mortality rates for PsA were similar to the general population, but the pandemic has raised concerns about a potential increased mortality risk for PsA patients due to COVID-19, warranting further investigation.
The aim of this study was to determine the distribution different types of osteoproliferative lesions on the lumbar spine and their relations in patients with psoriatic arthritis (PsA) under biologic-disease-modifying anti-rheumatic drug therapy. T12-S1 corners were evaluated in 182/274 (66.4%) patients with lumbar radiographs.
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