Publications by authors named "Given C"

While the coronavirus disease 2019 (COVID-19) pandemic has declined, many survivors continue to suffer debilitating symptoms, such as fatigue, pain, and foggy thoughts. Sustained COVID-19 symptoms, or Long COVID, challenge health care resources and economic recovery. This article describes the methodology, implementation, and results of an observational study investigating how time since diagnosis may affect lingering symptoms among the adult COVID-19 population.

View Article and Find Full Text PDF

Purpose: Three sequences of telephone symptom management interventions were tested on use of unscheduled health services among cancer survivors with depressive or anxiety symptoms during treatment (N = 334) and their informal caregivers (N = 333).

Methods: The three 12-week intervention sequences were as follows: (1) Symptom Management and Survivorship Handbook (SMSH), (2) a combined 8-week SMSH + Telephone Interpersonal Counseling (TIPC) followed by SMSH for 4 weeks, and (3) SMSH for 4 weeks followed by a combined SMSH + TIPC if no response to SMSH alone. Survivor-caregiver dyads were first randomized to SMSH or a combined SMSH + TIPC.

View Article and Find Full Text PDF
Article Synopsis
  • A study examined the factors that influence parents' decisions to consent to hair sample collection from their young children, focusing on 188 parent-child pairs.
  • 78% of parents consented to the collection, with notable differences in stress levels and coping strategies between those who did and did not participate.
  • Sociodemographic factors, such as the child's gender, parental marital status, and income, were linked to higher completion rates, prompting suggestions for tailored participation methods to enhance engagement in research.
View Article and Find Full Text PDF

Background: Flow diversion has revolutionized the management of wide-necked intracranial aneurysms (IAs). We aimed to assess the effectiveness and safety of the new generation 64-wire Surpass Evolve for the treatment of unruptured small/medium-sized IAs.

Methods And Results: This is a subanalysis from the SEASE (Safety and Effectiveness Assessment of the Surpass Evolve) registry, an observational cohort study including 15 academic institutions in North America and Europe between July 2020 and October 2022.

View Article and Find Full Text PDF
Article Synopsis
  • The study looked at whether a medical procedure called thrombectomy helps patients who have a large stroke as seen on a specific type of scan called a noncontrast CT within 24 hours of having the stroke.
  • It involved 300 patients from different hospitals who were split into two groups; one group received the thrombectomy treatment, while the other only received regular care.
  • The main goal was to see if those who had thrombectomy had better recovery after 90 days compared to those who didn’t, along with checking if there were any serious side effects.
View Article and Find Full Text PDF

Context: Many cancer survivors and their informal caregivers experience multiple symptoms during the survivor's treatment.

Objective: Test relative effectiveness and optimal sequencing of two evidence-based interventions for symptom management.

Methods: In this sequential multiple assignment randomized trial (SMART), survivors of solid tumors with elevated depression or anxiety and their caregivers as dyads were initially randomized after baseline assessment in a 3:1 ratio to the Symptom Management and Survivorship Handbook (SMSH, N = 277 dyads) intervention or SMSH plus 8 weeks of telephone interpersonal counseling (TIPC, N = 97 dyads).

View Article and Find Full Text PDF
Article Synopsis
  • - The Surpass Evolve (SE) is a new type of flow diverter used as the primary treatment for certain intracranial aneurysms, and its safety and effectiveness were evaluated in a large, multicenter study called SEASE, involving data from 305 patients treated between 2020 and 2022.
  • - Most patients in the study were female, had unruptured saccular aneurysms, and showed an average significant follow-up period during which 73% of aneurysms achieved complete occlusion.
  • - The findings indicate that SE demonstrates a high rate of effectiveness in closing aneurysms and exhibits a favorable safety profile, with low rates of major strokes and procedure-related mortality.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine how PROMIS scores for pain interference, physical function, fatigue, and depression impact the likelihood of cancer patients using emergency or urgent care services.
  • Analysis involved data from 952 cancer patients, focusing on their reported outcomes and subsequent healthcare utilization within 14 and 30 days.
  • Results showed that higher pain interference and lower physical function scores were linked to increased emergency visits, with specific score thresholds varying based on cancer stage, offering insights for clinical decision-making.
View Article and Find Full Text PDF

Context: Late or residual symptoms diminish quality of life for many cancer survivors after completion of treatment.

Objectives: Examine risk factors associated with persisting symptom burden after chemotherapy and the lack of symptom improvement over time.

Methods: Survivors who completed curative-intent chemotherapy within two years for solid tumors were enrolled into a symptom management trial.

View Article and Find Full Text PDF

Purpose: Bright light therapy holds promise for reducing common symptoms, e.g., fatigue, experienced by individuals with cancer.

View Article and Find Full Text PDF

Purpose: Bright light therapy holds promise for reducing common symptoms, e.g., fatigue, experienced by individuals with cancer.

View Article and Find Full Text PDF

Background: Physician variablity in preoperative planning of endovascular implant deployment and associated inaccuracies have not been documented. This study aimed to quantify the variability in accuracy of physician flow diverter (FD) planning and directly compares it with PreSize Neurovascular (Oxford Heartbeat Ltd) software simulations.

Methods: Eight experienced neurointerventionalists (NIs), blinded to procedural details, were provided with preoperative 3D rotational angiography (3D-RA) volumetric data along with images annotated with the distal landing location of a deployed Surpass Evolve (Stryker Neurovascular) FD from 51 patient cases.

View Article and Find Full Text PDF

Purpose: Although family involvement is critical to successful augmentative and alternative communication (AAC) device utilization, little is known about how families adapt to technology. The aim of this qualitative study was to explore parent-reported factors contributing to family adaptation among families with adolescents diagnosed with autism and/or Down syndrome (DS) utilizing AAC technology. This study describes families' experiences related to several interacting variables of the Resiliency Model, including demand, type, appraisal, resources, and problem-solving/coping, that helped shape the outcome of adaptation to AAC technology.

View Article and Find Full Text PDF

Conjugative plasmids can confer antimicrobial resistance (AMR) to their host bacterium. The plasmids disperse even between distantly related host species, rescuing the host from otherwise detrimental effects of antibiotics. Little is known about the role of these plasmids in the spread of AMR during antibiotic treatment.

View Article and Find Full Text PDF

Context: Many cancer survivors experience a lingering symptom burden after chemotherapy.

Objectives: In this sequential multiple assignment randomized trial, we tested optimal sequencing of two evidence-based interventions for symptom management.

Methods: Survivors of solid tumors (N = 451) were interviewed at baseline and stratified as high or low need for symptom management based on comorbidity and depressive symptoms.

View Article and Find Full Text PDF

Background: Many cancer survivors endure multiple symptoms while striving to return to a normal life. Those symptoms often co-occur and exacerbate one another; however, their interplay is not fully understood.

Objective: This study aimed to examine the occurrence and concurrence of sleep disturbance, fatigue, depressive mood, and cognitive dysfunction in posttreatment breast cancer survivors.

View Article and Find Full Text PDF

Despite music listening interventions (MLIs) being recommended in multiple clinical practice guidelines, implementation into oncology clinical practice sites has been slow. This mapping review aimed to critique and identify barriers to MLI clinical implementation, as well as offer practical solutions for both clinicians and researchers. A PRISMA-based mapping review of MLI literature was performed using CINAHL, PubMed, PsycINFO, and Web of Science databases.

View Article and Find Full Text PDF

Context: People on oral anti-cancer agents must self-manage their symptoms with less interaction with oncology providers compared to infusion treatments. Symptoms and physical function are key patient-reported outcomes (PROs) and may lead to unscheduled health services uses (urgent care and emergency department [ED] visits, hospitalizations), which in turn lead to increased health care costs.

Objectives: To evaluate the prediction of unscheduled health services uses using age, sex, and comorbidity, then determine the extent to which PRO data (symptoms and functioning) improve that prediction.

View Article and Find Full Text PDF

Aims: To identify and provide clarity on factors that influence coping and the type of coping strategies used by patients with heart failure (HF) to improve health-related quality of life (HRQoL).

Methods And Results: The Arksey and O'Malley template framed this scoping review guided by the stress and coping model. Five databases were explored: PubMed, Web of Science, Cochrane, CINAHL, and PsycINFO.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to identify factors that influence health service usage among cancer survivors and their caregivers during treatment.
  • The research involved 380 pairs of cancer survivors and their caregivers, analyzing self-reported health service usage and how it relates to social determinants of health.
  • Key findings indicated that the number of comorbid conditions and education level significantly affected scheduled care use, while younger age and health insurance availability led to higher unscheduled care usage, suggesting targeted educational initiatives for younger individuals could improve health service optimization.
View Article and Find Full Text PDF

Plasmids are extrachromosomal genetic elements, some of which disperse horizontally between different strains and species of bacteria. They are a major factor in the dissemination of virulence factors and antibiotic resistance. Understanding the ecology of plasmids has a notable anthropocentric value, and therefore, the interactions between bacterial hosts and individual plasmids have been studied in detail.

View Article and Find Full Text PDF
Article Synopsis
  • The pipeline embolization device (PED) has been shown to be a safe and effective treatment for small to medium brain aneurysms, with a study showing strong results after 3 years.
  • In a trial involving 141 patients, most had their aneurysms fully treated, and only a small number needed extra checks after the first year.
  • The PED showed a very low rate of major problems, with no serious ruptures and a high success rate of keeping the aneurysms from coming back.
View Article and Find Full Text PDF

More than one-third of cancer survivors experience significant residual symptoms after treatment completion. Fatigue and sleep disruption often co-occur and exacerbate each other. The purpose of this preliminary analysis was to examine the effect of a chronotypically tailored light therapy on fatigue and sleep disruption in female survivors 1-3 years post-completion of chemotherapy and/or radiation for stage I to III breast cancer.

View Article and Find Full Text PDF