Publications by authors named "Giusi Ruggiero"
We have shown that human B-cell non-Hodgkin lymphomas (B-NHLs) express heat shock protein (HSP)H1/105 in function of their aggressiveness. Here, we now clarify its role as a functional B-NHL target by testing the hypothesis that it promotes the stabilization of key lymphoma oncoproteins. HSPH1 silencing in 4 models of aggressive B-NHLs was paralleled by Bcl-6 and c-Myc downregulation.
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- Histone deacetylases (HDAC) are linked to the c-Myc oncogenic program, making HDAC inhibitors like ITF2357 promising for treating cancers that overexpress c-Myc, such as certain B-cell non-Hodgkin lymphomas (B-NHLs).
- In vitro studies showed ITF2357 slows down B-NHL cell growth by causing cell-cycle arrest and increasing cell death, which is connected to the downregulation of c-Myc protein through post-transcriptional mechanisms.
- In vivo experiments revealed that ITF2357 significantly reduced tumor growth in mice and, when combined with cyclophosphamide, led to complete remissions, highlighting its potential as a beneficial