Publications by authors named "Giuseppina Di Ruberto"
Article Synopsis
- Local protein synthesis at synapses has been shown to play a crucial role in brain plasticity, challenging the idea that protein synthesis mainly occurs in the cell body and dendrites.
- The study examined protein synthesis in TgCRND8 mice, which model Alzheimer's disease, finding differences in newly synthesized proteins at synapses compared to control mice, with some evidence of local APP synthesis.
- Results indicated that while control mice showed enhanced protein synthesis at synapses after learning tasks, TgCRND8 mice did not, suggesting that impaired local protein synthesis may contribute to the early development of Alzheimer's pathology.
The hippocampus (HP), a medial cortical structure, is subdivided into a distinct dorsal (septal) and ventral (temporal) portion, which is separated by an intermediate region lying on a longitudinal curvature. While the dorsal portion is more dedicated to spatial navigation and memory, the most ventral part processes emotional information. Genetic factors expressed in gradient during development seem to control the size and correct positioning of the HP along its longitudinal axis; however, their roles in regulating differential growth and in supporting its anatomical and functional dissociation remain unexplored.
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