Inhibition of nuclear factor-kappaB activation by IRFI 042, protects against endotoxin-induced shock.

Background: The aim of our study was to investigate the effect of IRFI 042, a novel dual vitamin E-like antioxidant, on nuclear factor-kappaB (NF-kappaB) activation, TNF-alpha gene priming and on the release of the mature protein during endotoxin shock.

Methods: Endotoxin shock was produced in male rats by a single intravenous (i.v.