Publications by authors named "Giuseppe Ricciardo-Lamonica"
Article Synopsis
- The study aimed to investigate the impact of the Glu298Asp polymorphism in the eNOS gene on sperm motility in infertile men with asthenozoospermia.
- Researchers analyzed genetic samples from 70 infertile men and 60 healthy men, finding the T allele more common in those with asthenozoospermia (60% vs 22.5% in the control group).
- Results indicated that men with the homozygous TT genotype had lower sperm motility percentages compared to those with the GG and GT genotypes, suggesting the T allele may negatively affect sperm motility.
The aim of the present study was to measure free thiols content, Na(+)/K(+)-ATPase and Ca(2+)-ATPase activities in human spermatozoa of asthenozoospermic patients and normospermic donors, and evaluate any influence on kinetic sperm features, as well as correlation with peroxynitrite. In fact, membrane integrity and its composition are the basic characteristics of the sperm membrane; thus, it is evident that its composition is an important factor for membrane functions that can be modified upon oxidation. A total of 70 infertile patients affected by idiopathic asthenozoospermia and 25 normal fertile donors were enrolled.
View Article and Find Full Text PDFObjective: To evaluate the effectiveness of coenzyme Q(10) treatment in improving semen quality in men with idiopathic infertility.
Design: Placebo-controlled, double-blind randomized trial.
Setting: Andrology Unit, Department of Internal Medicine, Polytechnic University of Marche, Italy.
Objective: To detect peroxynitrite and 3-nitrotyrosine production in human spermatozoa of asthenozoospermic infertile patients and normospermic donors, and evaluate any influence on kinetic sperm features.
Design: Basic study.
Setting: Andrology Unit, Dept of Internal Medicine and Biochemistry Institute, Polytechnic University of Marche, Italy.
Nitric oxide (NO) is a free radical generated from the oxidation of L-arginine to L-citrulline by 3 isoforms of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent NO synthases. Several data suggest a relevant role in sperm cell pathophysiology, but any conclusive data on its role in spermatozoa motility are still lacking. In the present study, we have correlated NO concentration in semen and kinetic features of sperm cells from normozoospermic fertile donors and infertile patients affected by idiopathic asthenozoospermia.
View Article and Find Full Text PDFObjective: To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia.
Design: Open, uncontrolled pilot study.
Patient(s): Infertile men with idiopathic asthenozoospermia.