Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo.

Granisetron is a 5-HT3 receptors antagonist used in the management of emesis associated with anticancer chemotherapy. It affects intestinal motility with constipating effect. Since the pathway heme oxygenase/carbon monoxide (HO/CO) is involved in gastrointestinal motility, we evaluated the possible interplay between granisetron and agents affecting HO/CO pathways such as zinc protoporphyrin IX (ZnPPIX), an HO inhibitor, or hemin, an HO-1 inducer.

Late embryonic exposure to all-trans retinoic acid induces a pattern of motor deficits unrelated to the developmental stage.

The present study extends previous investigations examining the behavioral outcomes of all-trans retinoic acid (RA) exposure at embryonic (E) days 14-16. A sublethal dose (2.5 mg/kg b.

Developmental omega-3 supplementation improves motor skills in juvenile-adult rats.

Long-chain polyunsaturated fatty acids are critical for brain growth spurt during both foetal and postnatal period. They play important roles in the expression of genes regulating cell differentiation and neuronal growth, as well as in the development of synaptic processing of neural cell interaction. Foetus and placenta are dependent on maternal supply for their growth and development, and supplemented infants show significantly greater mental and psychomotor scores.

Effects of early gestational all-trans retinoic acid treatment on motor skills: a longitudinal study in the offspring of Sprague-Dawley rats.

The purpose of the present study was to investigate the behavioral outcomes of all-trans retinoic acid (RA) treatment in the period spanning gestational day (GD) 8-10. A sublethal dose (2.5mg/kg b.

Parallel intestinal and liver injury during early cholestasis in the rat: modulation by bile salts and antioxidants.

Whereas long-term cholestasis results in intestinal alterations and increased permeability to hepatotoxins, the effect of short-term cholestasis is less known and was investigated in bile duct ligated (BDL) rats. In the intestinal mucosa, at Day 7 BDL, total glutathione and protein sulfhydryl contents had decreased, oxidized glutathione levels increased (P<0.05 vs baseline), and a reduced epithelium thickness with dissolving crypt phenomena was observed in 40% of rats.