Incidence of high chromogranin A serum levels in patients with non metastatic prostate adenocarcinoma.

Background: ChromograninA in prostate carcinoma (PC) indicate NE differentiation. This tumour is more aggressive and resistant to hormone therapy.

Patients And Methods: We analyzed the incidence of pre-operative ChromograninA serum levels in non metastatic PC patients.

Microalbuminuria in insulin sensitivity in patients with growth hormone-secreting pituitary tumor.

Context: Impaired glucose tolerance and diabetes mellitus are frequently present in acromegalic patients in whom the degree of impaired glucose metabolism seems directly correlated with GH levels. Microalbuminuria is reported to be directly correlated with insulin resistance, and both conditions predict cardiovascular disease mortality.

Objective: Our objective was to investigate the microalbuminuria levels as a marker of endothelial dysfunction in acromegalic patients.

Non-invasive evaluation of endothelial dysfunction in uncomplicated obesity: relationship with insulin resistance.

Obesity is associated with increased cardiovascular morbidity and amortality. Endothelial dysfunction, involved in the pathogenesis of cardiovascular events, has been demonstrated in obese patients with invasive techniques requiring artery catheterization. The aim of our investigation was to evaluate, with a non-invasive method readily employable on clinical grounds, impaired vasodilatation and its relationship with insulin resistance in uncomplicated obesity.