Publications by authors named "Giuseppe Cina"

The development of functional bionanocomposites for active food packaging is of current interest to replace non-biodegradable plastic coatings. In the present work, we report the synthesis of an alginate-based nanocomposite filled with modified halloysite nanotubes (HNTs) to develop coatings with improved barrier properties for food packaging. Firstly, HNTs were chemically modified by the introduction of carbon dots units (CDs) onto their external surface (HNTs-CDs) obtaining a nanomaterial where CDs are uniformly present onto the tubes as verified by morphological investigations, with good UV absorption and antioxidant properties.

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Recently, fluorescent sensors have gained considerable attention due to their high sensitivity, low cost and noninvasiveness. Among the different materials that can be used for this purpose, carbon dots (CDs) represent valuable candidates for applications in sensing. These, indeed, are easily synthesized, show high quantum yield and are highly biocompatible.

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The development of fluorescent materials that can act as sensors for the determination of metal ions in biological fluids is important since they show, among others, high sensitivity and specificity. However, most of the molecules that are used for these purposes possess a very low solubility in aqueous media, and, thus, it is necessary to adopt some derivation strategies. Clay minerals, for example, hectorite, as natural materials, are biocompatible and available in large amounts at a very low cost that have been extensively used as carrier systems for the delivery of different hydrophobic species.

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Invited for this month's cover are the collaborating groups of Prof. Serena Riela at University of Catania, Prof. César Viseras at University of Granada and Dr.

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Article Synopsis
  • Use of hydrogels in biomedicine is rising due to their ability to create targeted drug delivery systems, particularly with a focus on the development of a hydrogel using Laponite® clay and cucurbit[6]uril for flufenamic acid delivery.
  • Research included assessing the interaction between cucurbit[6]uril and flufenamic acid through UV-Vis spectroscopy and molecular modeling, followed by using this complex as a filler in the hydrogel.
  • The study evaluated the hydrogel's properties like viscosity and self-repair, examined its morphology, assessed stability and diffusion of the mixture, and investigated the in vitro release kinetics of flufenamic acid in a simulated skin environment.
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L-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have been developed in order to preserve its chemical stability, connected with its antioxidant power, but there is little research regarding the employment of natural clays as LAA host. A safe bentonite (Bent)-which was verified by in vivo ophthalmic irritability and acute dermal toxicity assays-was used as carrier of LAA.

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Bacterial infections represent one of the major causes of mortality worldwide. Therefore, over the years, several nanomaterials with antibacterial properties have been developed. In this context, clay minerals, because of their intrinsic properties, have been efficiently used as antimicrobial agents since ancient times.

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