What Is the Exact Contribution of and Genes in Clubfoot Development? An Italian Study.

Congenital clubfoot is a common pediatric malformation that affects approximately 0.1% of all births. 80% of the cases appear isolated, while 20% can be secondary or associated with complex syndromes.

High-permittivity pads to enhance SNR and transmit efficiency in MRI of the heart at 7T: a simulation study.

Objective: High-permittivity pads have shown promising results in enhancing SNR and transmit efficiency when used for MRI of the brain, but fewer studies have been conducted to examine the performance of high-permittivity pads in other parts of the patient. In this work, we evaluate the impact on SNR and transmit efficiency distributions when high-permittivity pads with different thickness are positioned near the chest of the patient in combination with a transmit/receive array coil.

Methods: The performance of the pads is evaluated through numerical simulations, and both the SNR distribution and the transmit efficiency maps are compared with those obtained when the pads are not present and the distance between the coils and the patient is minimal.

Neuronal activity under transcranial radio-frequency stimulation in metal-free rodent brains in-vivo.

As the use of Radio Frequency (RF) technologies increases, the impact of RF radiation on neurological function continues to receive attention. Whether RF radiation can modulate ongoing neuronal activity by non-thermal mechanisms has been debated for decades. However, the interactions between radiated energy and metal-based neural probes during experimentation could impact neural activity, making interpretation of the results difficult.

Improved whole-brain SNR with an integrated high-permittivity material in a head array at 7T.

Purpose: To demonstrate that strategic use of materials with high electric permittivity along with integrated head-sized coil arrays can improve SNR in the entire brain.

Methods: Numerical simulations were used to design a high-permittivity material (HPM) helmet for enhancing SNR throughout the brain in receive arrays of 8 and 28 channels. Then, two 30-channel head coils of identical geometry were constructed: one fitted with a prototype helmet-shaped ceramic HPM helmet, and the second with a helmet-shaped low-permittivity shell, each 8-mm thick.

Temperature-based MRI safety simulations with a limited number of tissues.

Purpose: Demonstrate ability to produce reasonable simulations of temperature using numerical models of the human body with a limited number of tissues.

Methods: For both a male and female human body model, numerical simulations were used to calculate temperature distributions in three different models of the same human body: the original model with 35 tissues for the male model and 76 tissues for the female model, a simplified model having only three tissues (muscle, fat, and lung), and a simplified model having six tissues (muscle, fat, lung, bone, brain, and skin).

Results: Although a three-tissue model gave reasonable specific absorption rate estimates in comparison to an original with many more tissues, because of tissue-specific thermal and physiological properties that do not affect specific absorption rate, such as rate of perfusion by blood, the three-tissue model did not provide temperature distributions similar to those of the original model.

Optimization of the order and spacing of sequences in an MRI exam to reduce the maximum temperature and thermal dose.

Purpose: Evaluate the possibility to reduce specific energy absorption rate (SAR)-induced maximum temperature and thermal dose by rearranging the order and spacing of sequences without increasing duration of the MRI examination.

Methods: Using numerical simulations based on an actual SAR-intensive MRI examination, optimizations to reduce either maximum temperature or thermal dose were performed. For each permutation of groups of sequences having the same patient table position, temperature and thermal dose were computed very rapidly using recently published methods.

Parallel transmission RF pulse design with strict temperature constraints.

RF safety in parallel transmission (pTx) is generally ensured by imposing specific absorption rate (SAR) limits during pTx RF pulse design. There is increasing interest in using temperature to ensure safety in MRI. In this work, we present a local temperature correlation matrix formalism and apply it to impose strict constraints on maximum absolute temperature in pTx RF pulse design for head and hip regions.

On the potential for RF heating in MRI to affect metabolic rates and FDG signal in PET/MR: simulations of long-duration, maximum normal mode heating.

Purpose: To examine the possibility that MR-induced RF power deposition (SAR) and the resulting effects on temperature-dependent metabolic rates or perfusion rates might affect observed 18FDG signal in PET/MR.

Methods: Using numerical simulations of the SAR, consequent temperature increase, effect on rates of metabolism or perfusion, and [18FDG] throughout the body, we simulated the potential effect of maximum-allowable whole-body SAR for the entire duration of an hour-long PET/MR scan on observed PET signal for two different 18FDG injection times: one hour before onset of imaging and concurrent with the beginning of imaging. This was all repeated three times with the head, the heart, and the abdomen (kidneys) at the center of the RF coil.

Effects of Anatomical Differences on Electromagnetic Fields, SAR, and Temperature Change.

Electromagnetic field simulations are increasingly used to assure RF safety of patients during MRI exams. In practice, however, tissue property distribution of the patient being imaged is not known, but may be represented with a pre-existing model. Repeatedly, agreement in transmit magnetic (B) field distributions between two geometries has been used to suggest agreement in heating distributions.

Perinatal Depression and Patterns of Attachment: A Critical Risk Factor?

Background. This study aims to verify if the presence and severity of perinatal depression are related to any particular pattern of attachment. Methods.

[Early attachement relationships and epigenetic customization].

Recently, new findings in epigenetic science switched the focus from the observation of physiological intragenomic dynamics to the idea of an environmental co-construction of phenotypic expression. In psichodynamic field, objectual relations and attachement theoreticians emphasized the interpersonal dimension of individual development, focusing the attention on the relational matrix of self organization. The construction of stable affective-behavioral traits throughout different parenting styles has actually found a coincidence in ethological studies, which have explored the epigenetic processes underlying the relationship between caregiving and HPA stress responsiveness.

[Perinatal depression and affective bonds: experience in close relationship during pregnancy].

Aim: This study aims to investigate the influence of the "romantic attachment" style, stressful life events, social factors on the risk of developing a depression during pregnancy and on the severity of depressive symptoms.

Methods: The study started with a screening on a sample of 453 women, during their third trimester of pregnancy, to which has been administered a survey data form, the Edinburgh Postnatal Depression Scale (EPDS) and the Experience in Close Relationship (ECR). Based on the results at EPDS, a clinical group of pre-natal depression (D=89) was selected and compared with a control group (C=89), in regards to psychopathological and social variables, exposure to stressful life events and attachment patterns.

Predicting long-term temperature increase for time-dependent SAR levels with a single short-term temperature response.

Purpose: Present a novel method for rapid prediction of temperature in vivo for a series of pulse sequences with differing levels and distributions of specific energy absorption rate (SAR).

Theory And Methods: After the temperature response to a brief period of heating is characterized, a rapid estimate of temperature during a series of periods at different heating levels is made using a linear heat equation and impulse-response (IR) concepts. Here the initial characterization and long-term prediction for a complete spine exam are made with the Pennes' bioheat equation where, at first, core body temperature is allowed to increase and local perfusion is not.

Consideration of the effects of intense tissue heating on the RF electromagnetic fields during MRI: simulations for MRgFUS in the hip.

Due to the strong dependence of tissue electrical properties on temperature, it is important to consider the potential effects of intense tissue heating on the RF electromagnetic fields during MRI, as can occur in MR-guided focused ultrasound surgery. In principle, changes of the RF electromagnetic fields could affect both efficacy of RF pulses, and the MRI-induced RF heating (SAR) pattern. In this study, the equilibrium temperature distribution in a whole-body model with 2 mm resolution before and during intense tissue heating up to 60 °C at the target region was calculated.

[Coffee consumption in depressive disorders: it's not one size fits all].

Caffeine is considered the world's most popular psychoactive substance. Its actions on the central nervous system, mainly mediated by antagonism of adenosine receptors and subsequent modulation of dopaminergic activity, would be particularly sought by depressed patients, as an attempt of self-medication. However, published data suggested that coffee consumption may worsen psychopathological conditions in mood disorders.

Measurement of SAR-induced temperature increase in a phantom and in vivo with comparison to numerical simulation.

Purpose: To compare numerically simulated and experimentally measured temperature increase due to specific energy absorption rate from radiofrequency fields.

Methods: Temperature increase induced in both a phantom and in the human forearm when driving an adjacent circular surface coil was mapped using the proton resonance frequency shift technique of magnetic resonance thermography. The phantom and forearm were also modeled from magnetic resonance image data, and both specific energy absorption rate and temperature change as induced by the same coil were simulated numerically.

A fast, analytically based method to optimize local transmit efficiency for a transmit array.

Purpose: To develop an analytically based algorithm for rapid optimization of the local radiofrequency magnetic (B1+) field intensity for a given radiofrequency power through a transmit array. The analytical nature of the method will yield insight to optimization requirements and provides a valuable reference for numerically based searches.

Methods: With the knowledge of the B1+ field distribution generated by each single coil of the array, both the phases and the amplitudes of each coil current are optimized to maximize the magnitude of the B1+ field in a specific location of the body per unit of power transmitted through the array and, consequently, minimizing the whole body specific absorption rate for a given pulse sequence.

An approach to rapid calculation of temperature change in tissue using spatial filters to approximate effects of thermal conduction.

We present an approach to performing rapid calculations of temperature within tissue by interleaving, at regular time intervals, 1) an analytical solution to the Pennes (or other desired) bioheat equation excluding the term for thermal conduction and 2) application of a spatial filter to approximate the effects of thermal conduction. Here, the basic approach is presented with attention to filter design. The method is applied to a few different cases relevant to magnetic resonance imaging, and results are compared to those from a full finite-difference (FD) implementation of the Pennes bioheat equation.

Radiofrequency field enhancement with high dielectric constant (HDC) pads in a receive array coil at 3.0T.

Purpose: To investigate the use of a new high-dielectric constant (HDC) material for improving SNR and transmission efficiency for clinical MRI applications at 3 Tesla (T) with cervical spine imaging.

Materials And Methods: Human subjects were imaged using a commercial cervical spine receive array coil on a clinical system with and without pads containing Barium Titanate beads in deuterium water placed around the neck. Numerical electromagnetic field simulations of the same configuration were also performed.

[Parental care and post partum depression: a case report].

The post partum depression (PPD) is a severe risk factor for the emotional and cognitive development of offspring. The Authors describe the relationship between mother with PPD and her two-year old child. The mother repeats patterns of parental care experienced during her own childhood.