Colorectal cancer and Crohn's colitis: clinical implications from 313 surgical patients.

Background: The relation between Crohn's colitis (CC) and colorectal cancer is still controversial. Several case reports and retrospective studies have shown that patients with Crohn's disease (CD) have a 6- to 20-fold higher risk to develop CRC than does the normal population. The extent of disease (extensive colitis), presence of anal fistula, age > 40 years, strictures, and length of disease >10 years may be important determinants for increasing risk.

The role of cytoreductive surgery alone for the treatment of peritoneal carcinomatosis of colorectal origin. A retrospective analysis with regard to multimodal treatments.

Background/aims: Patients with peritoneal carcinomatosis (PC) of colorectal origin have a poor prognosis (median survival of 6 months). Cytoreductive surgery (CS) with intra-peritoneal chemotherapy with or without hyperthermia (HIPEC or EPIC) allows encouraging survivals rates of 22-60 months to be obtained, with an acceptable mortality and morbidity. Nevertheless, the role of cytoreductive surgery alone is little explored in literature.

Ertapenem peritoneal fluid concentrations in adult surgical patients.

Ertapenem, a novel carbapenem, is approved for the treatment of mild to severe intra-abdominal infections (IAIs), although its in vivo concentrations in peritoneal fluid are unknown. The purpose of this study was to determine the peritoneal fluid concentration of ertapenem after a single 1 g intravenous dose. After informed consent, 21 patients (9 females and 12 males; mean+/-standard deviation (S.