Publications by authors named "Giuseppe Bucolo"

Objective: To investigate the potential role of dual-energy spectral computer tomography (CT) quantitative parameters in the definition of bladder cancer (BCa) pathological grading.

Methods: This retrospective study evaluated the use of spectral CT imaging features for BCa. From 2021 to 2023, 63 patients with histologically-confirmed BCa diagnosis were examined at our Institution.

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  • The study aimed to compare the effectiveness of dual-energy CT (DECT) iodine maps with traditional CT scans in diagnosing non-occlusive mesenteric ischemia (NOMI) using data from 142 patients who underwent surgery.
  • Findings showed that iodine concentration measurements in the late arterial phase provided superior diagnostic ability (AUC of 0.966) for identifying ischemic bowel compared to both portal venous phase and conventional CT scans.
  • The study concluded that late arterial phase iodine maps markedly enhance diagnostic accuracy for acute bowel ischemia, showing a very high sensitivity (100%) and specificity (96.48%) at a defined cutoff.
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Purpose: Preliminary dual-energy CT studies have shown that low-energy virtual monoenergetic (VMI) + reconstructions can provide superior image quality compared to standard 120 kV CTA series. The purpose of this study is to evaluate the impact of low-energy VMI reconstructions on quantitative and qualitative image quality, vascular contrast, and diagnostic assessability of the carotid artery in patients undergoing photon-counting CTA examinations.

Materials And Methods: A total of 122 patients (67 male) who had undergone dual-source photon-counting CTA scans of the carotid artery were retrospectively analyzed in this study.

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Background: We evaluated the role of dual-energy computed tomography (DECT)-based collagen maps in assessing thoracic disc degeneration.

Methods: We performed a retrospective analysis of patients who underwent DECT and magnetic resonance imaging (MRI) of the thoracic spine within a 2-week period from July 2019 to October 2022. Thoracic disc degeneration was classified by three blinded radiologists into three Pfirrmann categories: no/mild (grade 1-2), moderate (grade 3-4), and severe (grade 5).

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Purpose: To evaluate a deep learning-based pipeline using a Dense-UNet architecture for the assessment of acute intracranial hemorrhage (ICH) on non-contrast computed tomography (NCCT) head scans after traumatic brain injury (TBI).

Materials And Methods: This retrospective study was conducted using a prototype algorithm that evaluated 502 NCCT head scans with ICH in context of TBI. Four board-certified radiologists evaluated in consensus the CT scans to establish the standard of reference for hemorrhage presence and type of ICH.

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  • Lumbar disk degeneration is a common cause of back pain, and this study aimed to assess the effectiveness of dual-energy CT (DECT)-derived collagen maps in evaluating its severity.
  • The research analyzed data from 127 patients who had both DECT and MRI scans, categorizing the level of disk degeneration using a scale and calculating the accuracy and sensitivity of DECT maps compared to MRI.
  • Results showed that DECT collagen maps had a high accuracy rate (85.5%) for diagnosing different stages of degeneration, suggesting their potential use in situations where MRI is not an option.
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Background: Despite a considerable amount of literature on dual-energy CT (DECT) iodine uptake of the head and neck, the physiologic iodine uptake of this region has not been defined yet. This study aims to establish reference values for the iodine uptake of healthy organs to facilitate clinical application.

Methods: Consecutive venous DECT scans of the head and neck were reviewed, and unremarkable exams were included ( = 617).

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Purpose: To evaluate the diagnostic performance of a dual-energy computed tomography (DECT)-based material decomposition algorithm for iodine quantification and fat fraction analysis to detect lymph node metastases in breast cancer patients.

Materials And Methods: 30 female patients (mean age, 63.12 ± 14.

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Background: This study aimed to evaluate the clinical utility of modern single and dual-energy computed tomography (CT) for assessing the integrity of the cruciate ligaments in patients that sustained acute trauma.

Methods: Patients who underwent single- or dual-energy CT followed by 3 Tesla magnetic resonance imaging (MRI) or knee joint arthroscopy between 01/2016 and 12/2022 were included in this retrospective, monocentric study. Three radiologists specialized in musculoskeletal imaging independently evaluated all CT images for the presence of injury to the cruciate ligaments.

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: To evaluate if coronary CT angiography (CCTA) monoenergetic reconstructions, obtained with a dual-layer spectral detector computed tomography (DLCT) system, offer improved image quality compared with 120 kVp conventional images without affecting the quantitative assessment of coronary stenoses. : Fifty CCTA datasets (30 men; mean age: 61.6 ± 12.

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  • The study focused on using radiomic features and dual-source dual-energy CT (DECT) parameters to distinguish between benign and malignant mediastinal masses and predict patient outcomes.
  • It analyzed data from 90 patients with confirmed mediastinal masses, demonstrating significant differences in DECT parameters and radiomic features between benign and malignant cases.
  • The findings indicated high accuracy in differentiating between the two types of masses and showed that a combination of these imaging techniques could effectively predict patient mortality risk over a follow-up period.
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Dual-layer Dual-Energy CT (dl-DECT) allows one to create virtual non-contrast (VNC) reconstructions from contrast-enhanced CT scans, with a consequent decrease of the radiation dose. This study aims to assess the reliability of VNC for the diagnostic evaluation of renal masses in comparison with true non-contrast (TNC) images. The study cohort included 100 renal masses in 40 patients who underwent dl-DECT between June and December 2021.

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  • Cancer patients are at a higher risk for venous thromboembolism (VTE), but traditional D-dimer testing combined with clinical assessment may not be as effective in this group.
  • D-dimer levels can help rule out VTE, and if elevated beyond ten times the normal limit, may indicate a high probability of VTE with over 80% positive predictive value, while also providing prognostic information about cancer severity and potential outcomes.
  • There is a need for standardizing D-dimer testing protocols and creating tailored models for assessing cancer patients to improve diagnostic accuracy for VTE.
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Purpose: To compare conventional CT images and virtual monoenergetic images (VMI) at dual-layer dual-energy CT (dlDECT) in patients with colorectal cancer (CRC) through quantitative analysis and to investigate the added value of VMI.

Material And Methods: Sixty-six consecutive patients with histologically documented CRC and available VMI reconstructions were retrospectively investigated. Subsequently, forty-two patients, without any colonic disease at colonoscopy, were selected as control group.

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Background: Type 2 diabetes mellitus (DM) is the most common metabolic disorder in the world and an important risk factor for peripheral arterial disease (PAD). CT angiography represents the method of choice for the diagnosis, pre-operative planning, and follow-up of vascular disease. Low-energy dual-energy CT (DECT) virtual mono-energetic imaging (VMI) has been shown to improve image contrast, iodine signal, and may also lead to a reduction in contrast medium dose.

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The technological development of Artificial Intelligence (AI) has grown rapidly in recent years. The applications of AI to cardiovascular imaging are various and could improve the radiologists' workflow, speeding up acquisition and post-processing time, increasing image quality and diagnostic accuracy. Several studies have already proved AI applications in Coronary Computed Tomography Angiography and Cardiac Magnetic Resonance, including automatic evaluation of calcium score, quantification of coronary stenosis and plaque analysis, or the automatic quantification of heart volumes and myocardial tissue characterization.

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Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as "tumor-like" lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from complete lack of symptoms to acute coronary syndrome or sudden cardiac death.

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Pneumothorax and pneumomediastinum are life-threatening conditions especially in critically ill patients. One of the most common situations in which they occur is prolonged invasive and non-invasive mechanical ventilation with high end-expiratory pressure. Probably due to the high number of patients with SARS-CoV-2 respiratory infection being treated with mechanical ventilation, increasing number of pulmonary barotrauma cases have been reported.

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