Publications by authors named "Giulietta Anna Perrone"
Hypoxia-inducible factor-1α (HIF-1α) is frequently overexpressed and activated in many cancer types. However, its regulation and function in thyroid carcinomas are only partially known. Aim of our study was to demonstrate that adaptation to the hypoxic micro-environment by human papillary thyroid carcinoma (PTC) cells, in the absence of leukocyte infiltrate, induces a "molecular inflammation" process characterized by the expression of a large set of genes normally involved in inflammation.
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- The study investigates the expression patterns of estrogen receptor (ER) isoforms in human papillary thyroid carcinoma (PTC) using advanced techniques like laser-capture microdissection and real-time quantitative PCR.
- The results demonstrate significantly higher expression levels of ER-α mRNA and protein in cancerous cells compared to surrounding normal tissue, while ER-β mRNA was not detected.
- The findings suggest that ER-α could serve as a potential marker for malignancy in PTC, with implications for diagnosis and treatment.
Background: Ano-genital carcinoma is a polyfactorial and polygenic disease. Certain strains of human papillomavirus (HPV) have been detected in a high percentage of patients. It has been suggested that p53 polymorphisms may be relevant for the interaction with viral proteins that inactivates p53.
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