Publications by authors named "Giuliana Xavier de Medeiros"
Article Synopsis
- The study investigates the effects of blocking interleukin-10 (IL-10) and PD-1 on controlling HIV/SIV viral rebound after stopping antiretroviral therapy (ART).
- In a trial with rhesus macaques, a combination treatment of anti-IL-10 and anti-PD-1 led to sustained control of viral levels in 9 out of 10 monkeys for over 24 weeks post-treatment interruption.
- Outcomes indicated that specific immune responses, such as increased memory T cells and changes in cytokine levels, could predict successful viral control after ART cessation.
Introduction: Considering the likely need for the development of novel effective vaccines adapted to emerging relevant CoV-2 variants, the increasing knowledge of epitope recognition profile among convalescents and afterwards vaccinated with identification of immunodominant regions may provide important information.
Methods: We used an RBD peptide microarray to identify IgG and IgA binding regions in serum of 71 COVID-19 convalescents and 18 vaccinated individuals.
Results: We found a set of immunodominant RBD antibody epitopes, each recognized by more than 30% of the tested cohort, that differ among the two different groups and are within conserved regions among betacoronavirus.