Publications by authors named "Giuliana Petrelli"
Background And Objectives: The European Medicine Agency extended the use of Comirnaty, Spikevax, and Nuvaxovid in paediatrics; thus, these vaccines require additional real-world safety evidence. Herein, we aimed to monitor the safety of COVID-19 vaccines through Covid-19 Vaccine Monitor (CVM) and EudraVigilance surveillance systems and the published pivotal clinical trials.
Methods: In a prospective cohort of vaccinees aged between 5 and 17 years, we measured the frequency of commonly reported (local/systemic solicited) and serious adverse drug events (ADRs) following the first and second doses of COVID-19 vaccines in Europe using data from the CVM cohort until April 2022.
Article Synopsis
- Conventional vaccines are generally safe with mild allergic reactions, but mRNA-based COVID-19 vaccines showed higher risks of severe allergies compared to standard vaccines.
- A literature review was conducted to examine the frequency, risk factors, and mechanisms of allergic reactions related to COVID-19 vaccines, using MEDLINE, Google Scholar, and other databases for data analysis.
- The study also compiled recommendations from scientific societies and regulatory agencies for preventing and managing allergic reactions to COVID-19 vaccines, particularly for individuals with previous allergies.