Publications by authors named "Giuliana Lopez-Navarrete"
A novel application of diffuse reflectance and fluorescence spectroscopy in the assessment of liver fibrosis is here reported. To induce different stages of liver fibrosis, a sufficient number of male Wistar rats were differentially exposed to chronic administration with carbon tetrachloride. Then, diffuse reflectance and fluorescence spectra were in vivo measured from the liver surface of each animal by a minimal invasive laparoscopic procedure.
View Article and Find Full Text PDFArticle Synopsis
- Cirrhosis results from liver fibrosis and is worsened by Kupffer cell-related inflammation; however, alternatively-activated macrophages may help manage inflammation and promote healing.
- In a study using carbon tetrachloride to induce liver damage in mice, researchers inoculated some with Taenia crassiceps to stimulate alternative activation in Kupffer cells.
- The findings indicated that the Tc-inoculated mice had lower levels of inflammation and fibrosis compared to non-inoculated ones, suggesting that alternatively-activated Kupffer cells can both reduce inflammation and potentially worsen fibrosis in a chronic liver injury setting.