Publications by authors named "Giulia Visani"
Rho guanine nucleotide exchange factor (RGNEF) is a guanine nucleotide exchange factor (GEF) mainly involved in regulating the activity of Rho-family GTPases. It is a bi-functional protein, acting both as a guanine exchange factor and as an RNA-binding protein. RGNEF is known to act as a destabilizing factor of neurofilament light chain RNA (NEFL) and it could potentially contribute to their sequestration in nuclear cytoplasmic inclusions.
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- - The study investigates the role of specific heterogeneous nuclear ribonucleoproteins in amyotrophic lateral sclerosis (ALS), focusing on their connection with TAR DNA-binding protein 43 kDa, which is implicated in ALS pathology.
- - Researchers found that a certain mRNA is a direct target of TAR DNA-binding protein 43 kDa, and manipulating its levels in fly models can alleviate related ALS symptoms.
- - In human patients, decreased levels of this mRNA are linked to TAR DNA-binding protein 43 kDa-related protein issues, suggesting it could be a promising target for developing new treatments for ALS.