Publications by authors named "Giulia T M Getti"
Article Synopsis
- Leishmania parasites are spread to mammals (like humans) by sandfly bites and can infect different types of immune cells, but the immune response differs between mice and humans.
- In a study focused on human infection, researchers analyzed immune responses using fresh blood samples and flow cytometry, discovering that neutrophils and monocytes make up the majority of cells responding in the initial hours.
- Interestingly, the study also identified a significant presence of CD4 T cells among the leukocytes, suggesting they might play a role in the early stages of Leishmania infection.
Development of human leishmaniasis is dependent on the ability of intracellular Leishmania parasites to spread and enter macrophages. The mechanism through which free promastigotes and amastigotes bind and enter host macrophages has been previously investigated; however, little is known about intracellular trafficking and cell-to-cell spreading. In this study, the mechanism involved in the spreading of Leishmania aethiopica and Leishmania mexicana was investigated.
View Article and Find Full Text PDFThe catechin, epigallocatechin gallate (eGCG), found in green tea, has inhibitory activity against a number of protein toxins and was investigated in relation to its impact upon ricin toxin (RT) in vitro. The IC(50) for RT was 0.08±0.
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