Quantifying the impact of an abrupt reduction in mineral nitrogen fertilization on crop yield in the European Union.

Contemporary crop production in Europe relies on nitrogen (N) fertilization. Fertilizer prices soared in 2021-2022, and remained at historical high levels in 2023. These high prices invoked an immediate concern on the possible consequences for Europe's food production.

Integrating Geophysical and Multispectral Data to Delineate Homogeneous Management Zones within a Vineyard in Northern Italy.

Soil electrical conductivity (EC) maps obtained through proximal soil sensing (i.e., geophysical data) are usually considered to delineate homogeneous site-specific management zones (SSMZ), used in Precision Agriculture to improve crop production.

Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis.

Interleukin (IL)-21 triggers inflammatory signals that contribute to the growth of neoplastic cells in mouse models of colitis-associated colorectal cancer (CRC). Because most CRCs are sporadic and arise in the absence of overt inflammation we have investigated the role of IL-21 in these tumors in mouse and man. IL-21 was highly expressed in human sporadic CRC and produced mostly by IFN-γ-expressing T-bet/RORγt double-positive CD3+CD8- cells.

IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism.

Unlabelled: Fulminant hepatitis (FH) is a disease characterized by massive destruction of hepatocytes with severe impairment of liver function. The pathogenesis of FH is not fully understood, but hyperactivity of T cells and macrophages with excessive production of cytokines are important hallmarks of the condition. In this study, we investigated the role of interleukin (IL)-25 in FH.