Publications by authors named "Giulia Pirini"
Posterior mediastinal tumors are not infrequent, and among them neurogenic masses and schwannomas are the most common histologic varieties. These benign, initially asymptomatic tumors later become symptomatic as a result of mass effect. Surgical excision is the preferred therapy, and the approach can be determined according to the dimensions of the lesion.
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- - The study focuses on quadruple wild-type (WT) gastrointestinal stromal tumors (GIST), which lack common mutations but maintain an intact SDH complex; it aimed to better characterize this genomic subgroup through comprehensive genetic analysis.
- - Whole exome sequencing (WES) revealed an average of 18 somatic mutations per sample, with significant mutations found in genes like TP53 and MEN1, while differential expression analysis identified unique mRNA and miRNAs specifically associated with quadruple WT GIST.
- - The findings indicate that quadruple WT GIST has a distinct genetic profile, displaying similarities to neuroendocrine tumors, which opens up possibilities for tailored treatment strategies based on their unique biology.
Desmoid tumours have a strong tendency for local invasion and recurrence. A 70 year-old male presented with cervical and left shoulder pain associated with a supraclavicular mass. The computed-tomography showed an expansive lesion measuring 10 cm × 6 cm × 5.
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