Publications by authors named "Giulia Passarella"
Context: The mechanisms underlying bone fragility and increased fracture risk observed in individuals with type 2 diabetes (T2D) are not yet fully elucidated. Previous research has suggested a role for neuropeptides in regulating bone metabolism; however, the contribution of the neuropeptide Neurotensin (NT), which is thoroughly implicated in T2D and cardiovascular disease, has not been investigated in this context.
Objective: To study the relationship between circulating levels of the NT precursor proneurotensin (proNT) and bone mineralisation in T2D women.
Type 2 diabetes mellitus (T2DM) is associated with an increased fracture risk. Our study aimed to explore differences in bone alterations between T2DM women and controls and to assess clinical predictors of bone impairment in T2DM. For this observational case control study, we recruited 126 T2DM female patients and 117 non-diabetic, age- and BMI-comparable women, who underwent clinical examination, routine biochemistry and dual-energy X-ray absorptiometry (DXA) scans for bone mineral density (BMD) and trabecular bone score (TBS) assessment-derived indexes.
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- - This study examines how liver fibrosis impacts bone health in obese people with non-alcoholic fatty liver disease (NAFLD), revealing a significant connection between increased liver fibrosis and lower bone mineral density (BMD) and microstructure.
- - In a sample of 1,872 obese individuals, those with conditions like osteopenia or osteoporosis had notably higher levels of liver fibrosis (FIB-4 scores), with these scores correlating negatively with factors like osteocalcin and IGF-1, which are important for bone health.
- - The findings suggest that higher levels of liver fibrosis are predictive of increased bone fragility, even after adjusting for other variables such as age, sex, and BMI, highlighting the importance of monitoring bone