Publications by authors named "Giulia Marconcini"
Context: Patients with amiodarone-induced thyrotoxicosis (AIT) often receive initial therapy for thyrotoxicosis in several different medical settings before admission to a referral center.
Objective: This work aimed to determine whether first-line medical therapy (ie, therapies for thyrotoxicosis at first diagnosis of AIT) affects the outcome of AIT patients.
Methods: A single-center historical-prospective cohort study was conducted on 313 AIT patients.
Serum thyrotropin (TSH) receptor antibodies (TRAbs) are occasionally found in patients with amiodarone-induced thyrotoxicosis (AIT), and usually point to a diagnosis of type 1 AIT (AIT1) due to Graves' disease (GD). However, the TRAb role and function in AIT have not been clarified. A retrospective cohort study of 309 AIT patients followed at a single academic center over a 30-year period.
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- - PCB153, a common pollutant, reduces apoptosis (cell death) in pituitary cells by affecting various cellular pathways.
- - The study involved exposing murine pituitary cells to PCB153 and using multiple methods to assess apoptosis, revealing that it decreases cell death through both intrinsic and extrinsic pathways.
- - PCB153 triggers the PI3K/Akt pathway and activates NF-κB, leading to reduced levels of pro-apoptotic proteins like p38-MAPK, p53, and p21, which helps promote cell survival.
Article Synopsis
- - Patients with amiodarone-induced thyrotoxicosis (AIT) and low left ventricular ejection fraction (LVEF) face high mortality rates, which may be mitigated by total thyroidectomy, but the timing of surgery remains unclear.
- - A study of 64 patients revealed that those with low LVEF who had surgery after becoming euthyroid had significantly higher mortality rates compared to those who were still thyrotoxic at the time of surgery (40% versus 0% peritreatment mortality).
- - Factors like age and duration of thyrotoxicosis are significant predictors of mortality, whereas the timing of surgery (whether during thyrotoxicosis or after) appears to have a
Article Synopsis
- A study was conducted to evaluate the effectiveness of total thyroidectomy versus medical therapy in patients with amiodarone-induced thyrotoxicosis (AIT), focusing on survival and heart function over 20 years.
- The results indicated that patients who underwent total thyroidectomy had lower overall and cardiac-specific mortality rates compared to those receiving medical therapy, particularly among those with severe heart dysfunction.
- The research suggests that total thyroidectomy may be the better option for AIT patients with significant heart issues, while its benefits are less clear for individuals with mild heart conditions.
Context: Therapy with somatostatin analogues (SSAs) may have deleterious effects on glucose metabolism in patients with acromegaly, often leading to the development of diabetes mellitus (DM).
Aim: The aim of the study was to evaluate whether DM, developed during therapy with SSAs, may revert after drug withdrawal and cure of acromegaly with pituitary adenomectomy.
Design: Retrospective cohort study, in a tertiary referral centre.
Objective: The primary objective of this study is to identify the predictors of comorbidities and major adverse cardiovascular events (MACE) that can develop after diagnosis of acromegaly. The role of therapy for acromegaly in the event of such complications was also evaluated.
Design And Methods: Retrospective cohort study was conducted on 200 consecutive acromegalic patients in a tertiary referral center.
Background: Approximately 60% of sporadic medullary thyroid carcinomas (sMTC) remain orphan of a recognized genetic cause. Recently, a high percentage of RAS point mutations have been described in RET-negative sMTC. The aim of this study was to assess the prevalence of RAS point mutations in a large series of MTC collected in four Italian centers.
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