Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection.

Background: Liver metastases of breast cancer are frequent and can recur even after "complete/R0" resection in combination with systemic and hormonal treatments. The aim of this study was to analyze throughout repeat hepatectomies for liver metastases the evolution of PI3KCA gene mutational status.

Methods: All liver metastases nodules (n = 70) from 19 women who underwent at least 2 liver resections were reexamined.