Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients.

Importance: Squamous cell carcinoma (SCC) is the most frequent malignant neoplasm found in solid organ transplant recipients and is associated with a more aggressive disease course and higher risk of metastasis and death than in the general population.

Objectives: To report the clinicopathologic features of and identify factors associated with aggressive SCC in solid organ transplant recipients.

Methods: This retrospective multicentric case series included 51 patients who underwent solid organ transplantation and were found to have aggressive SCC, defined by nodal or distant metastasis or death by local progression of primary SCC.

Impaired coronary flow reserve in young patients affected by severe psoriasis.

Objective: Our study aimed to evaluate the effects of psoriasis (Pso) on coronary microvascular function and whether there is a relationship between disease activity scores and coronary blood flow abnormalities.

Methods: 56 young patients (pts) with Pso (42 M, aged 37±3 years) without clinical evidence of cardiovascular diseases, and 56 controls matched for age and gender were studied. Coronary flow velocity in the left anterior descending coronary artery was detected by transthoracic echocardiography at rest and during adenosine infusion.

A case-control study on family dysfunction in patients with alopecia areata, psoriasis and atopic dermatitis.

Family history can provide important information about a patient's psychological status, and thus their disease risk. A multicentric case-control study on family dysfunction was performed on 59 patients with psoriasis (63.7%), atopic dermatitis (11.

Psoriasis and Psyche--what's new? What is clinically relevant?

The last decades have witnessed an increasing interest in psychological aspects of chronic skin disease. Psoriasis has received much attention, partly due to the pivotal change brought to therapeutic concepts by biologics. This article aims to provide a brief overview, with no claims on exhaustiveness, on recent (i.