The calcium-sensing receptor modulates the prostaglandin E pathway in intestinal inflammation.

The prostaglandin E (PGE) pathway is one of the main mediators of intestinal inflammation. As activation of the calcium-sensing receptor (CaSR) induces expression of inflammatory markers in the colon, we assessed the impact of the CaSR on the PGE pathway regulation in colon cancer cells and the colon and . We treated CaSR-transfected HT29 and Caco-2 colon cancer cell lines with different orthosteric ligands or modulators of the CaSR and measured gene expression and PGE levels.