Publications by authors named "Gitsch E"

Article Synopsis
  • The review discusses the historical ties between the medical centers of the University of Berlin (Charité) and the University of Vienna.
  • It highlights the current state of these institutions and their medical research practices.
  • The text also offers suggestions for future development to improve their collaboration and advancements.
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Article Synopsis
  • The management of ovarian cancer at Vienna University's First Department of Obstetrics and Gynecology has evolved significantly over time.
  • Improvements in radical surgery techniques and a more thoughtful use of adjuvant treatments have contributed to better outcomes.
  • As a result, there has been an increase in the 5-year survival rates for patients during the most recent review period.
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Aside from the more common perioperative and postoperative dysfunctions of micturition, urogenital fistulas represent the most frequent complication encountered after surgical gynecologic interventions. Vesicovaginal fistulas are the most common communication between efferent urinary passages and the genital tract. From 1967 to 1987, 42 women had a vesicovaginal fistula develop after abdominal or vaginal operations and underwent another operation.

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Besides a relatively high frequency of perioperative and postoperative dysfunctions of micturition, urogenital fistulae are the most frequent complication occurring after surgical gynaecological interventions. Vesico-vaginal fistulae are the most common communication between the efferent urinary passages and the genital tract. From 1967 to 1987, 42 women who had developed a vesico-vaginal fistula after abdominal or vaginal surgery or irradiation were operated on again.

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Two sampling methods, biopsy and cell smear, were investigated for their reliability in the biotin in-situ hybridization test for human papilloma virus deoxyribonucleic acid (HPV-DNA)-6/11 and 16/18. Cervical smears and biopsies were obtained simultaneously from 81 women with cervical lesions. The sensitivity of the in-situ hybridization was tested on human cervical carcinoma cell lines.

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A historical review is given on the installation of the Department of Radiotherapy of the 1st Department of Obstetrics and Gynecology and its further development to the Department of Irradiation of the 1st and 2nd Department of Obstetrics and Gynecology at the Vienna University. The milestones of the last 40 years like the change to the "New Stockholm Method" (1954), the new construction and adaptation (1968-1972) with the installation of a telecobalt-therapy-unit (1972), the conjunction of the department of radiotherapy of both university departments to a single department in the same year and finally the introduction of the after-loading method in brachytherapy (1980) are pointed out specifically.

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The relative advantages and disadvantages of the transabdominal versus the transvaginal approach to hysterectomy were evaluated and the two procedures were compared for differences in hospitalization, patient age, bowel activity and operating time on the basis of a material of 94 hysterectomized patients. Intestinal complications such as subileus were noted only in subjects who were treated by abdominal hysterectomy. This corresponded with the significant decrease in potassium in abdominally operated patients on the second post-surgical day.

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Besides the relatively frequent perioperative and postoperative dysfunctions of micturition, urogenital fistulae are the most frequent complication occurring after surgical gynaecologic interventions. Vesico-vaginal fistulae are the most common communication between efferent urinary passages and genital tract. From 1969 to 1986, 36 women developed a vesico-vaginal fistula after abdominal or vaginal surgery and were operated on again.

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Article Synopsis
  • The study focused on the use of intraperitoneal chemotherapy for post-surgical treatment of ovarian cancer, involving 24 patients.
  • Among those with bulky disease, results showed a high complication rate and poor therapeutic outcomes.
  • However, patients with microscopic disease and residual tumors smaller than 2 cm appeared to benefit from the treatment, despite Mitoxantrone causing local discomfort and potential peritonitis.
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A new strategy for tumor detection using immunoscintigraphic techniques was used in an attempt to improve the diagnostic potential of conventional external immunoscintigraphy. Twelve patients who were strongly suspected to either suffer from primary or recurrent ovarian cancer were investigated as follows: radioimmuno-scintigraphy (RIS) by means of radiolabelled antibodies was performed in all patients prior to operation (first or second look). During the operative procedure, which always took place immediately after completion of the diagnostic RIS, a hand-held gamma-ray detection probe, especially developed for this purpose was used for the purpose of identifying radiolabelled tumor sites intra-operatively in the open abdomen.

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During the period 1970-1981 radioisotope radical surgery was performed in 270 patients suffering from cervical carcinoma stage Ib und II. During the development of the method, which has a three-stage process, the rate of cases with complete lymphadenectomy was increased from 52.5% to 75.

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Article Synopsis
  • A hand-held gamma-ray detection probe was created to solve issues with traditional radio-immunoscintigraphy (RIS) during surgeries.
  • The probe aims to enhance radionuclide-assisted surgery (RAS) for ovarian cancer by improving tumor localization and detecting radio-active antibodies.
  • In a study involving twelve patients, RAS successfully identified tumor tissue during surgery, but the probe requires further enhancements to be clinically valuable.
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The diagnostic possibilities of immunoscintigraphy (IS) in ovarian cancer are discussed. Seventy-five patients were investigated by IS using the radioantibodies HMFG-2 (n = 63) or OC-125 (n = 12). The results showed a specificity of 75%, sensitivity of 87%, and accuracy of 84%.

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After a historical outlook on the development of radical vaginal hysterectomy, our own results and complications in 51 cases of stages I and II during the years 1968-1983 are reported. The 5-year survival rate was 98.04% with no primary mortality.

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Radio-isotope radical operation has been developed in three steps. The rate of complete lymphadenectomies determined by the complete removal of labelled tissue was increased from 52.2% in the first observation period to 67.

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Article Synopsis
  • The study examined postoperative changes in various acute-phase proteins and endocrine parameters in 40 healthy women.
  • Two groups of 20 women each underwent either vaginal or abdominal hysterectomy.
  • Significant differences were found in levels of alpha 1-antitrypsin, CRP, and myoglobin based on the type of surgery, but most other parameters showed no notable differences.
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Postoperative changes in various acute-phase-proteins (alpha 1-Antitrypsin, c-reactive protein), alpha 2-Macroglobulin, haptoglobin, transferrin. c3-c4-complement and myoglobin as well as endocrine parameters were studied in forty healthy women in two groups. Women with malignant neoplasms were excluded.

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Within two years 341 amenorrheic patients treated in our endocrinological outpatient department were listed up retrospectively in WHO-classification groups. In 30 patients a primary amenorrhea and in 311 patients a secondary amenorrhea could be registered. In 28.

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