Publications by authors named "Gita Paulikova"
O-methylation is an unusual sugar modification with a function that is not fully understood. Given its occurrence and recognition by lectins involved in the immune response, methylated sugars were proposed to represent a conserved pathogen-associated molecular pattern. We describe the interaction of O-methylated saccharides with two β-propeller lectins, the newly described PLL2 from the entomopathogenic bacterium Photorhabdus laumondii, and its homologue PHL from the related human pathogen Photorhabdus asymbiotica.
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- A newly discovered bangle lectin (PHL) from the bacterium Photorhabdus asymbiotica primarily binds to fucose and may influence host-pathogen interactions and immune responses.
- PHL is a homo-dimer with multiple L-fucose binding sites, and various ligands, including calix[4]arenes and dendrimers, were tested for their effectiveness using a stable C-glycosidic bond.
- The dendrimers showed significantly higher binding affinity to PHL compared to free L-fucose, with crystal structures confirming that the ligands occupied most of PHL's binding sites.