Publications by authors named "Gita Dangol"
Background & Aims: RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The impact of RNF43 mutations on PDAC is poorly understood and autochthonous models have not been characterized sufficiently. In this study, we describe a genetically engineered mouse model (GEMM) of PDAC with conditional expression of oncogenic Kras and deletion of the catalytic domain of Rnf43 in exocrine cells.
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- * It builds causal networks and uses advanced modeling to show that certain metabolites, influenced by these mutations, can predict risks for conditions like hypertension and heart attacks.
- * Ultimately, the research highlights how integrating genetic data with metabolomic analyses can enhance our understanding of the links between genes and complex diseases.