Treatment of aggressive basal cell carcinoma with intralesional interferon: evaluation of efficacy by Mohs surgery.

Background: Intralesional interferon has shown activity in the treatment of noduloulcerative and superficial basal cell carcinomas (BCC).

Objective: Our purpose was to study the efficacy of intralesional interferon in the treatment of aggressive BCCs.

Methods: Fifteen patients with histologically proven primary morpheaform or recurrent BCCs were referred for Mohs surgery.

Trichophyton rubrum abscesses in immunocompromised patients. A case report.

A 72-year-old immunocompromised man with myelodysplastic syndrome who developed multiple erythematous, scaly abscesses like lesions on his left foot and lower leg is described. He also had dry scaly lesions on his soles and lesions on several toe nails. A punch biopsy showed abscesses with fungal elements and Trichophyton rubrum was cultured from skin scales and the biopsy.

Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA).

The analgesic effect of a lidocaine/prilocaine cream (EMLA) for the curettage of molluscum contagiosum was evaluated in 55 children aged 3-14 years. Five to 25 molluscs per child were covered with a maximum of 10 g EMLA cream one hour before the operation. The pain was rated as either none or slight by 93% of the children while the physician's assessment was 96%.

Identification of basal cell carcinomas by means of monoclonal antibodies C50 and C241.

The monoclonal antibodies C50 and C241 with specificities for the carcinoma-associated carbohydrate structures sialylated Lea and sialosyllactotetraose, respectively, were used in the indirect immunofluorescent test for demonstration of malignant cells in patients with basal cell carcinoma (BCC). Among a total of 36 patients with BCC, 33 were positive with the MAb C50, and 30 with the MAb C241. All of five patients with premalignant conditions were positive with both antibodies, whereas none of 31 control individuals (biopsies from normal skin or from patients with non-malignant conditions) showed a positive reaction.

A comparative study of the therapeutic effect of dithranol cream 0.1% and 0.25% with that of dithranol stylus 0.1% and 0.2% in the treatment of psoriasis.

In Dithranol cream the oily phase is emulsified with an aqueous phase to make the preparation more convenient to apply. The cream also contains ascorbic acid as an antioxidant, which protects dithranol against atmospheric oxidation, thus increasing its stability. A stylus containing dithranol, ol.

Histological and histochemical investigations of lupus erythematosus in the skin and the oral mucosa.

Skin and oral lesions of chronic discoid lupus erythematosus from 6 patients have been investigated histologically and histochemically. Intra-individual comparisons between skin and oral lesions and intrasection comparisons between clinically affected and unaffected regions were performed. Enzyme histochemical recordings consisted of oxido-reductase and hydrolase activities.