Publications by authors named "Gislene G de Castro Lichs"
This study examines the epidemiological and genomic characteristics, along with the transmission dynamics, of SARS-CoV-2 within prison units I and II in Campo Grande, Mato Grosso do Sul, Brazil. Conducted between May and October 2022, it reveals how the virus spreads in the confined settings of prisons, emphasizing the roles of overcrowded cells, frequent transfers, and limited healthcare access. The research involved 1927 participants (83.
View Article and Find Full Text PDFArticle Synopsis
- The rising spread of arboviruses and increasing infection rates emphasize the urgent need for improved methods to rapidly and accurately detect these pathogens.
- This study focuses on combining nanopore sequencing with reverse transcription polymerase chain reaction (RT-PCR) to create a multiplex RT-PCR protocol.
- The new protocol allows the simultaneous detection of multiple viruses, including Chikungunya, dengue, Zika, yellow fever, and West Nile, enhancing our ability to differentiate between arbovirus strains effectively.
Genomic surveillance has emerged as a crucial tool in monitoring and understanding the dynamics of viral variants during the COVID-19 pandemic. In the Midwest region of Brazil, Mato Grosso do Sul has faced a significant burden from the SARS-CoV-2 epidemic, with a total of 613,000 confirmed cases as of June 2023. In collaboration with the Central Public Health Laboratory in the capital city of Campo Grande, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate the circulation of the Omicron variant in the region.
View Article and Find Full Text PDFArticle Synopsis
- * Collaborative efforts led to the collection of 422 chikungunya virus genomes from 12 states, offering insights into how the virus has spread and evolved across the country.
- * Analysis of the genetic data revealed two distinct subclades of the virus and highlighted Northeast Brazil as the main spreading region, with immune system factors potentially influencing its genetic diversity.
Article Synopsis
- Mosquito-borne diseases like Yellow Fever, Zika, Chikungunya, and Dengue are causing big health problems in Brazil, especially since Chikungunya started spreading in 2014.
- In two years (2021-2022), scientists created 422 new virus genomes from 12 states to better understand how Chikungunya spreads, as there were over 312,000 reported cases.
- They discovered that the northeast region of Brazil is the main area where the virus is spreading to other places and found that certain factors in the immune system might be changing the virus's genes in Brazil.
Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV in Brazil, generating 227 novel genome sequences of DENV1-2 from 85 municipalities (2015-2019). This equated to an over 50% increase in the number of DENV genomes from Brazil available in public databases.
View Article and Find Full Text PDF