Publications by authors named "Gislene Collobert"
Reliable diagnostic methods are mandatory for effective management of infection. Histology and culture are the most common invasive methods in current practice, even if molecular methods are gaining in importance. The performance of these conventional methods varies significantly.
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- * Researchers analyzed the genetic and phenotypic characteristics of GAS strains, finding that most belonged to the emerging emm89 clade 3, sharing similar molecular markers and displaying consistent biofilm formation and interactions with lung cells and immune cells.
- * The findings indicate that specific genetic mutations did not correlate with the severity of infections, highlighting the strain's ability to cause significant outbreaks among vulnerable patients due to its inherent phenotypic traits.
Sixty-three cases of Streptococcus pyogenes meningitis in adults were studied. Three predominant emm types were associated with meningitis: emm1 (44%), emm3 (11%), and emm6 (11%). Streptococcal toxic shock syndrome and mortality rates were 40% and 38%, respectively.
View Article and Find Full Text PDFLinezolid has emerged as an important therapeutic option for the treatment of Staphylococcus aureus in patients with cystic fibrosis. We report the rapid emergence, upon treatment with linezolid, of linezolid-resistant S. aureus clinical isolates through the accumulation of resistance-associated 23S rRNA mutations, together with acquisition of an altered mutator phenotype.
View Article and Find Full Text PDFWe characterized 182 Streptococcus dysgalactiae subsp. equisimilis isolates and analyzed the epidemiological data on the corresponding infections. stG6, stG485, and stG6792 were the 3 most prevalent invasive emm types among the 27 different emm types recovered.
View Article and Find Full Text PDFBackground & Objectives: A limited number of biotypes, T-types, and emm-types have been found to be associated with invasive isolates of group A streptococci, confirming the involvement of the M protein in virulence and its importance as an epidemiological marker. In this study, the epidemiological markers in the clinical isolates of group A streptococci were compared in invasive and non invasive isolates.
Methods: From 1998 to 2001, 141 invasive and 353 non invasive isolates in France were studied and their biotype, T-type, and emm-type were determined.