Publications by authors named "Gislane Santos"
Article Synopsis
- The long-term effects of COVID-19, known as Post-Acute Sequelae of COVID-19 (PASC), are becoming a major public health issue linked to poor recovery of organs and abnormal immune responses post-infection.
- A mouse model was developed to study patients with respiratory PASC, revealing unique immune cell interactions that disrupt lung cell regeneration and contribute to lung fibrosis after initial infection.
- Interventions targeting certain inflammatory signals were found to improve lung recovery, suggesting potential therapeutic strategies to address fibrosis that develops from respiratory viral infections.
The long-term physiological consequences of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are rapidly evolving into a major public health concern. The underlying cellular and molecular etiology remain poorly defined but growing evidence links PASC to abnormal immune responses and/or poor organ recovery post-infection. Yet, the precise mechanisms driving non-resolving inflammation and impaired tissue repair in the context of PASC remain unclear.
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