Publications by authors named "Gisele Freitas Gauze"
Article Synopsis
- - The study evaluated a new hybrid compound derived from oxadiazol-4-methoxynaphthalene for its potential to inhibit a specific virus and clinical isolates, alongside its interaction with anti-tuberculosis drugs.
- - Researchers determined the minimal inhibitory concentration, conducted time kill curve assays, and assessed pharmacokinetics and cytotoxicity to understand the effectiveness and safety of the compound.
- - The findings suggest that the newly synthesized molecule shows promising anti-viral activity with low toxicity, making it a candidate for further development as an anti-TB drug.
Article Synopsis
- Researchers aimed to find inhibitors for homoserine dehydrogenase (HSD) to combat paracoccidioidomycosis, a serious infection in Brazil with high mortality rates.
- They performed virtual screenings using modeling tools like Autodock, Molegro, and Gold programs, identifying two promising compounds, HS23 and HS87, which were ranked higher than the substrate and showed no toxicity.
- Experimental assays demonstrated that both compounds exhibited effective minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values, as well as synergistic effects with Amphotericin B (AmB), indicating their potential as viable drug candidates.
Synthesis of 1,3,4-oxadiazoles with 4-methoxynaphthalene ring: discovering new compounds with antimicrobial activity.
Future Med Chem
December 2023
Paracoccidioidomycosis (PCM) is a systemic infection caused by spp. (). PCM can be associated or clinically confused with tuberculosis (TB), another pulmonary infection, caused by ().
View Article and Find Full Text PDFExploration of essential oil from Psychotria poeppigiana as an anti-hyperalgesic and anti-acetylcholinesterase agent: Chemical composition, biological activity and molecular docking.
J Ethnopharmacol
October 2022
Ethnopharmacological Relevance: Leaves from Psychotria poeppigiana Müll. Arg. (accepted as Palicourea tomentosa (Aubl.
View Article and Find Full Text PDFParacoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides spp., which mainly affects workers in rural regions of Latin America. Although the antifungal agents currently available for the treatment of PCM are effective in controlling the disease, many months are needed for healing, making the side effects and drug interactions relevant.
View Article and Find Full Text PDFPsychotria leiocarpa Extract and Vincosamide Reduce Chemically-Induced Inflammation in Mice and Inhibit the Acetylcholinesterase Activity.
Inflammation
October 2019
Species from Psychotria are used in folk medicine against inflammatory diseases, respiratory disturbances, and anti-hallucinogenic. In the present study, the compound vincosamide (PL-1) was identified for the first time in methanolic extract of the Psychotria leiocarpa (ME-PL) leaves, as well as the anti-inflammatory and anticholinesteric effects in rodents and molecular docking simulations. The fractionation of the chloroform fraction (CF-PL) through chromatographic methods afforded the known compound PL-1.
View Article and Find Full Text PDFAim: Evaluating carvacrol, derivatives and carvacrol plus anti-TB (anti-tuberculous) drug combination activities in Mycobacterium tuberculosis as well as carvacrol cytotoxicity, efflux pump inhibitor activity and morphological changes in M. tuberculosis HRv.
Methods: Carvacrol (CAR) and derivatives' activities were determined by resazurin microtiter assay and drug interaction by resazurin drug combination microtiter.