Amperometric determination of NADH and dehydrogenase enzymes at a redox-active nanocomposite.

Aminated carbon nanotubes, CNT, were covalently modified with glutardialdehyde (GDI) and the redox dye Azure to form a new electrode material CNT-GDI-Azure (CGA). The nanocomposite of CGA and polysaccharide chitosan was used for the anodic determination of NADH. Compared to conventional carbon and metal electrodes, the CGA electrode drastically lowered the overpotential for NADH oxidation (by > 0.

Characteristics of progression to tyrosine kinase inhibitors predict overall survival in patients with advanced non-small cell lung cancer harboring an mutation.

Background: Non-small cell lung cancer (NSCLC) harboring EGFR-sensitizing mutations has a distinct biology and heterogeneous clinical behavior. We evaluated the characteristics to progression such as clinical patterns of progression (dramatic, gradual, and local) with the prognosis of NSCLC patients treated with tyrosine kinase inhibitors (TKIs).

Methods: We reviewed 123 advanced-NSCLC patients with an EGFR-sensitizing mutation treated with TKIs (gefitinib, erlotinib and afatinib).

One-Year Feasibility Study of Replenish MicroPump for Intravitreal Drug Delivery: A Pilot Study.

Purpose: To determine the feasibility of the surgical procedure and to collect some safety data regarding the bioelectronics of a novel micro drug pump for intravitreal drug delivery in a Beagle dog model for up to 1 year.

Methods: Thirteen Beagle dogs were assigned to two groups. The experimental group ( = 11) underwent pars plana implantation of MicroPump; the body of which was sutured episclerally, while its catheter was secured at a pars plana sclerotomy.