Analgesic and anti-inflammatory activity of podophyllotoxin derivatives.

Context: Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use, such as etoposide, teniposide and etopophos. Reumacon, another semisynthetic derivative, reached its clinical phase for the treatment of rheumatoid arthritis.

Objective: This study investigated the analgesic and anti-inflammatory properties of three compound derivatives from podophyllotoxin.