Pyrrolidinohydroquinazolines--a novel class of CCR3 modulators.

A novel class of CCR3 modulators is described. Starting with lead compound 4a (K(i): 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (K(i): 28 nM), which surprisingly proved to be an agonist.