Advances in pathogenesis and precision medicine for nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) is a squamous carcinoma with apparent geographical and racial distribution, mostly prevalent in East and Southeast Asia, particularly concentrated in southern China. The epidemiological trend over the past decades has suggested a substantial reduction in the incidence rate and mortality rate due to NPC. These results may reflect changes in lifestyle and environment, and more importantly, a deeper comprehension of the pathogenic mechanism of NPC, leading to much progress in the preventing, screening, and treating for this cancer.

Cassia tora extract alleviates Aβ aggregation processes in vitro and protects against aluminium-induced neurodegeneration in rats.

Objectives: To examine the ability of Cassia tora extract to produce, in vitro and in vivo, beneficial effects with respect to events occurring during Alzheimer's disease.

Methods: Previously characterised methanol extract of C. tora was tested for its ability to lessen Aβ aggregation processes in vitro and to alleviate aluminium-induced impairments in vivo in rats.

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle.

Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the severity of the hemorrhage itself as well as multiple deleterious effects of blood and its breakdown products such as hemin and free iron. While oxidative injury and genomic damage have been seen following ICH, the details of this injury and implications remain unclear. Here, we discovered that, while free iron produced mostly reactive oxygen species (ROS)-related single-strand DNA breaks, hemin unexpectedly induced rapid and persistent nuclear and mitochondrial double-strand breaks (DSBs) in neuronal and endothelial cell genomes and in mouse brains following experimental ICH comparable to that seen with γ radiation and DNA-complexing chemotherapies.

Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways.

In the long term, diabetes profoundly affects multiple organs, such as the kidney, heart, brain, liver, and eyes. The gradual loss of function in these vital organs contributes to mortality. Nonetheless, the effects of diabetes on the lung tissue are not well understood.

Linn. Induces Protection against DNA and Membrane Damage.

Background: is a medicinal herb used to cure various ailments in subtropical and tropical regions of Southeast Asia.

Objective: The objective of this evaluation of against free radical induced DNA and erythrocyte damage.

Materials And Methods: The profiles of polyphenol and flavonoid were quantified through reversed-phase high-performance liquid chromatography.

Neuroprotective effects of Cassia tora against paraquat-induced neurodegeneration: relevance for Parkinson's disease.

The aim of the present study was to determine whether Cassia tora extracts could reverse the oxidative stress-induced neurodegeneration in a Parkinson's disease in vitro model. The leaves were treated with ethyl acetate (CtEA) or methanol (CtME). The extracts were first analysed by HPLC for their phenolic content and then tested for their neuroprotective effects in human SK-N-SH neuroblastoma cells.

Evaluation of Linn. against Oxidative Stress-induced DNA and Cell Membrane Damage.

Objective: The present study aims to evaluate antioxidants and protective role of Linn. against oxidative stress-induced DNA and cell membrane damage.

Materials And Methods: The total and profiles of flavonoids were identified and quantified through reversed-phase high-performance liquid chromatography.

Protein glycation and aggregation inhibitory potency of biomolecules from black gram milled by-product.

Background: Persistent hyperglycaemia causes increased advanced glycation end products (AGEs), which contribute to the pathogenesis of diabetic complication. Therefore, effect of black gram milled by-product (BGBP) extract on inhibition of AGE formation in a bovine serum albumin (BSA)/glucose system was investigated.

Results: BGBP extract had a total polyphenol content of 82 mg GAE g and flavonoid content of 46 mg CE g .

Protection of DNA and erythrocytes from free radical induced oxidative damage by black gram (Vigna mungo L.) husk extract.

Antioxidants present in various plant tissues exhibit health benefits by scavenging reactive oxygen species generated under various pathophysiological conditions. In the present study, bioactive compounds from black gram husk were extracted with water and the protection of black gram husk (BGH) extract against oxidative damage in DNA and erythrocytes were studied. BGH extract had total polyphenol content of 59 mg of gallic acid equivalents (GAE).