Publications by authors named "Girish Raparti"
Thyroid hormone (TH) is known to have many beneficial effects on vital organs, but its extrapolation to be used therapeutically has been restricted by the fact that it does have concurrent adverse effects. Recent finding of various thyroid hormone receptors (TR) isoforms and their differential pattern of tissue distribution has regained interest in possible use of TH analogues in therapeutics. These findings were followed by search of compounds with isoform-specific or tissue-specific action on TR.
View Article and Find Full Text PDFPathogenesis and treatment of human immunodeficiency virus lipodystrophy.
Indian J Endocrinol Metab
March 2012
Enhanced understanding about the way human immunodeficiency virus (HIV) infects and causes infection in humans has led to invention and use of newer more effective antiretroviral drugs. As treatment for HIV is long term, side effects of the antiretrovirals become an important area of research focus. Antiretrovirals can cause severe metabolic abnormalities, collectively known as HIV lipodystrophy syndrome.
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- Diabetes mellitus is a chronic condition that requires effective management for optimal blood sugar control, and bromocriptine offers a new treatment approach by resetting the body's circadian rhythms.
- In a study involving 105 participants, three different treatment groups were established to evaluate the efficacy and safety of bromocriptine QR compared to metformin.
- Results indicated that while bromocriptine alone led to significant improvements in blood sugar levels, combining it with metformin resulted in even greater reductions, though with a slightly higher occurrence of side effects.