Virtual Screening and Identification of Novel Oxindole Derivatives as Potential Antimicrobial Agents.

Introduction: Antimicrobial resistance (AMR), according to the World Health Organi-zation, is one of the most serious risks to global public health and development. It is a serious health hazard, with over 10 million deaths expected by 2050. New treatment materials and ways to remove AMR pathogens are in great demand to combat illnesses caused by such bacteria.

Effect of thermal annealing on an emissive layer containing a blend of a small molecule and polymer as host for application in OLEDs.

In order to improve the performance of OLEDs, a host-guest mixture was used as an emissive layer. To have better host properties, a mixture of different materials with suitable properties can also be used as a host. In this study, we used a mixture of a polymer and a small molecule as the host and studied the effect of thermal annealing on the emissive layer properties by using Ir(ppy) as the emitter.

Detection of bacterial contaminants via frequency manipulation of amino-groups functionalized FeOnanoparticles based resonant sensor.

Bacterial infections have a large impact on public health. Through this study, we report on the development of complementary split-ring resonators (CSRR) supplemented by functionalized nanoparticles to detect bacteria in the aqueous medium. Iron oxide (FeO) nanoparticles were functionalized with amino groups using (3-aminopropyl) triethoxysilane (APTES) to form (APTES@FeO) nanoparticles, which have a specific affinity towards the bacterial species.

Cervical Lymph Node Evaluation in Oral Squamous Cell Carcinoma Patients Using Ultrasound-Guided Fine-Needle Aspiration Cytology - A Descriptive Diagnostic Evaluation Study in a Tertiary Care Center.

Background: Oral cancer is the most frequent type of cancer of the head and neck area, with squamous cell carcinoma (SCC) being the most common single entity. Worldwide, oral cancer accounts for 2%-4% of all cancer cases, the prevalence being highest in India. Lymph node metastases occur in about 40% of patients with oral cancer.

Comparative evaluation of platelet-rich fibrin, platelet-rich fibrin + 50 wt% nanohydroxyapatite, platelet-rich fibrin + 50 wt% dentin chips on odontoblastic differentiation - An study-part 2.

Aim: The purpose of this study was to investigate the effects of platelet-rich fibrin (PRF) modified with bioactive radiopacifiers-nanohydroxyapatite (nHA) and dentin chips (DC) on odontoblastic differentiation in human dental pulp cells (HDPCs).

Subjects And Methods: PRF was modified with 50wt% of nHA (G bone-SHAG31, Surgiwear Company) and 50 wt% of DC. HDPSCs differentiation and mineralization by the groups ([Group A - Control (Dimethyl sulfoxide), Group B - PRF, Group C - PRF + nHA, Group D - PRF + DC]) were assessed.

Efficient and tunable shape selective synthesis of Ag/CeO nanostructures modified highly stable SERS substrate for ultrasensitive detection of pesticides on the surface of an apple.

Detection of pesticide residues from fruits and vegetables is of significant importance to ensuring human health and environmental safety. An efficient and tunable shape-selective synthesis of Ag/CeO nanostructures as an active flexible SERS substrate for the detection of thiram on an apple surface a paste, peel off, and paste again process was performed. The well-controlled formation of silver assembled CeO microspheres constituting nanospheres and nanospindles with an average size of approximately 56 and 32 nm with anisotropic structures has been confirmed through morphological and crystallographic analysis.

Molecular docking and dynamics studies of 4-anilino quinazolines for epidermal growth factor receptor tyrosine kinase to find potent inhibitor.

A series of novel 4-anilino quinazoline derivatives were taken based on the literature study and optimized with Autodock version 4.2 and molecular dynamics (MD) protocol to investigate the interaction between the target compounds and the amino acid residues of target protein epidermal growth factor receptor (EGFR) tyrosine kinase (PDB ID: 1M17). The free energies of binding and inhibition constants (Ki) of the docked ligands were calculated by the Lamarckian genetic algorithm (LGA).

Surface morphology-dependent room-temperature LaFeO₃ nanostructure thin films as selective NO₂ gas sensor prepared by radio frequency magnetron sputtering.

In the present work, perovskite LaFeO3 thin films with unique morphology were obtained on silicon substrate using radio frequency magnetron sputtering technique. The effect of thickness and temperature on the morphological and structural properties of LaFeO3 films was systematically studied. The X-ray diffraction pattern explored the highly oriented orthorhombic perovskite phase of the prepared thin films along [121].

Rhizobium subbaraonis sp. nov., an endolithic bacterium isolated from beach sand.

Two strains (JC85(T) and JC108) of Gram-stain-negative, motile bacteria were isolated from endolithic beach sand samples on an oligotrophic medium. Based on the 16S rRNA gene sequence analysis, both strains were identified as belonging to the genus Rhizobium. Strain JC108 had 16S rRNA gene sequence similarity of 100 % with Rhizobium pusense NRCPB10(T) and formed a cluster with this strain.

3-(4-Bromo-phen-yl)quinazolin-4(3H)-one.

In the title compound, C(14)H(9)BrN(2)O, the quinazoline unit is essentially planar, with a mean deviation of 0.058 (2) Å from the least-squares plane defined by the ten constituent ring atoms. The dihedral angle between the mean plane of the quinazoline ring system and the 4-bromo-phenyl ring is 47.

Hepatoprotective activity of Musa paradisiaca on experimental animal models.

Objective: To investigate the hepatoprotective activity of stem of Musa paradisiaca (M. paradisiaca) in CCl4 and paracetamol induced hepatotoxicity models in rats.

Methods: Hepatoprotective activity of alcoholic and aqueous extracts of stem of M.

3-(4-Chloro-phen-yl)quinazolin-4(3H)-one.

In the title compound, C(14)H(9)ClN(2)O, the quinazoline unit is essentially planar, with a mean deviation from the least-squares plane defined by the ten constituent ring atoms of 0.027 (2) Å. The dihedral angle between the mean plane of the quinazoline ring system and the 4-chloro-phenyl ring is 44.

Osteomyelitis of Maxilla in Infantile Osteopetrosis: A Case Report with Review of Literature.

Osteopetrosis is a rare genetic disorder that causes generalized sclerosis of bone due to a defect in bone resorption and remodeling. It is usually manifesting in two basic forms: An autosomal dominant benign form (osteopetrosis tarda) and an autosomal recessive malignant form (osteopetrosis congenita). A third form, the intermediate recessive type, has also been reported.

Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus.

Objective: To investigate the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of Amaranthus caudatus, Amaranthus spinosus and Amaranthus viridis in normal and streptozotocin (STZ) induced diabetic rats.

Methods: In this study, the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of all three plants was evaluated by using normal and STZ induced diabetic rats at a dose of 200 mg/kg and 400 mg/kg p.o.

Novel heliobacteria of a few semi-arid tropical soils.

Out of forty rhizosphere soils collected from semi arid tropical regions of Andhra Pradesh, India, 30 gave positive enrichments for heliobacteria. These bacteria were recognized by the presence of bacteriochlorophyll-g together with endospores in the initial enrichments. Using group specific primers of 16S rRNA gene, ten monoheliobacterial cultures were sequenced.

Effect of doping on the morphology and multiferroic properties of BiFeO3 nanorods.

In this study we report the synthesis of BiFeO(3) nanorods using a sonochemical technique. The nanorods had a diameter of 20-50 nm, a length of 100-500 nm and exhibit aspect ratios in the range of 5-10. However, after doping, the TEM images of Bi(0.

Rhodobacter johrii sp. nov., an endospore-producing cryptic species isolated from semi-arid tropical soils.

An oval to rod-shaped, phototrophic, purple non-sulfur bacterium, strain JA192(T), was isolated from an enrichment culture of a pasteurized rhizosphere soil sample from a field cultivated with jowar (sorghum) collected from Godumakunta village near Hyderabad, India. Strain JA192(T) is Gram-negative, motile and produces endospores. Phylogenetic analysis on the basis of 16S rRNA gene sequences showed that the strain JA192(T) is closely related to Rhodobacter sphaeroides 2.

Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone marrow mononuclear cells.

Background: Peripheral arterial disease is a significant problem worldwide. In developing countries such as India, the increased incidence of smoking and other forms of nicotine intake has resulted in a large proportion of young individuals with Buerger's disease. The results of surgical and endovascular treatment for this condition have not been very rewarding.

Anti-nociceptive effect of synthesized di-hydroxy flavones: possible mechanism.

Renewed interest on the research on the flavonoids is gaining more importance. Earlier literature on flavonoids indicated a significant anti-nociceptive action for flavones and mono-substituted flavones. However, they exhibited a ceiling effect.

Partial purification of tumour reducing principle from Helicanthis elasticus (Fam. Loranthaceae).

Extracts from plants of Loranthaceae family collected from 15 host trees were screened for their cytocidal activity to tumour cells. Biologically active extracts prepared from Helicanthis elasticus grown on Mangifera indica and Citrus maxima (host trees) were partially purified by the gel filtration method. The purified material was found to be cytotoxic in vitro and reduced solid and ascites tumours in mice when given either simultaneously or prophylactically.